Thanks for posting this.
This is pretty big news in the biz, but it appears to me that the significant thing isn't an algorithmic breakthrough but the realization that the one-molecule-thick cryo technique results in a consistent orientation that enables them to filter the data. That's really remarkable. BTT
Remember, all this happened by chance, with lots of time thrown in.
And don’t forget that these proteins can be Right-Handed or Left-Handed.
It must have been sorted out by those million monkeys on the typewriters...
Need I say /sarc?
Solving 3D protein structure has revolutionized drug discovery. Several of my potential drugs have been placed into the active sites of targeted enzymes and X-ray structures solved from the crystals grown. Any process that speeds this up will be a great leap forward.
Bookmark
Bookmark.