Regions develop, flourish, fade and stagnate. Can’t restore prosperity by willing it so in an area which lacks the relevant resources. Best thing to do is give people luggage and a bus ticket.
What resources does Appalachia not have?
What resources does Communist China have that Appalachia doesn’t?
Free Trade Stupidity, along with other Liberal stupidity, kills Appalachia. If you can ship a factory to Communist China...you can ship it to Appalachia