Absolutely.
Do I think some should be more equal than others? Nope, but I’m talking about the real world, not your (or my) opinion of how the world ought to be.
For instance, when was the last time you heard of a court decision settled on the basis of an appeal to the 9th or 10th Amendments? They’re there in the text, but they have no effect in the real world.
The 2nd Amendment was largely ignored and misapplied for most of the last century, only lately being given some small part of the respect given the first Amendment.
3rd Amendment is a dead letter. Conditions have changed to the point where it just doesn’t apply.
7th Amendment is completely ignored, especially with regard to the $20 amount specified.
Ha! The First amendment is also dead; it's been dying since at least 1919 (Schenec).
(One could also argue the Alien & Sedition acts in John Adam's presidency.)