She did that in (an independent film that is) The Good Girl in 2002. It was a rather sad and dark film but I have to say that she carried off the role pretty well; she wasnt very likable and that was the point.
I also liked her in Marley & Me and of course in Office Space.
The Breakup was another movie I thought she did well in. Unfortunately, that was promoted as a typical rom-com and it was nothing of the kind.