If one is not familiar with the route, going Westbound, one can end up getting off of I-80, and onto the Skyway. Toll roads to deal with there, too. No big deal for the junk in the trunk as long as nothing accidental happens, but still a consideration. Heavy traffic around Chicago. Main travel hours are murder. Can stretch until late in the evening, too.
There are other ways across from Central Ohio that can miss Chicago. Get a good, large book type Atlas. In truck stops the paperback binding kind can usually be had for less than ten dollars. I always used the ring binder type. More expensive, but I was driving without any electronic nav aids. All old fashioned maps.
Oh, wait. Some backroad areas in Ohio, also watch for Amish buggys going real slow. Those small towns can be loaded with traffic cops too. Be smart, and not in a big rush.
Some cell phones can give one maps and direction, but there isn't quite anything like having a map one can hold in their hands, even if also using the electronic stuff of any type (smart phone, or gps).
For long range driving, we would always figure 50 mph average. One can beat that with an automobile, particularly in States which may have varying speed limits for trucks and passenger cars. Yet to maintain that average over available working hours, one would still need to keep their butt in the seat, and their hands upon the wheel.
You'll be on I-80 most of the way? There shouldn't be much trouble. Don't be paranoid of course, but consider "rush hours" when transiting any metropolitan area. Rush hours it can be a little crowded around places not real big, like Davenport Iowa, Des Moines, Omaha Lincoln, Nebraska, but not too bad. There's a real beauty of a truckstop near Grand Island, Nebraska. Exit 312. Has some sections salvaged from the World Trade Center on display. Near Davenport, but a bit West there is "The Largest Truckstop in the World". It's not a big deal to me... I don't think the food is all that good. Hell, I'd park at the Pilot on the South side of the Interstate if I had a delivery the following morning in the Davenport area, just to save the time getting in and out of the joint, and crossing over the highway.
Avoid Indianapolis if possible and practical too, that is if your Ohio location is in the Southern part, which could well lead you through Indy. Heavy traffic...a few cops on the side of the road here and there, both East and West...they will nail drivers for little over in "town".
Haven't been driving OTR for about ten months, but would expect there still to be some construction around Indy, and maybe on the West side I-70 too, out some miles. Someone else could weigh in with more specifics.