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To: LomanBill
If marijuana is legalized, everyone who wants it will be growing it; and not the weak rope they were smoking in 1929 either - but genetically selected, brain frying, psycho weed.

Some will smoke stronger, some weaker - just like some drink beer and some drink Everclear. The nation has survived legal hard liquor and we'll survive legal weed, Chicken-Little-meets-Reefer-Madness hysteria notwithstanding.

56 posted on 03/05/2012 9:27:14 AM PST by JustSayNoToNannies (A free society's default policy: it's none of government's business.)
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To: JustSayNoToNannies

Chicken-Little-meets-Reefer-Madness hysteria

Abstract

It has long been known that cannabis can elicit an acute psychotic reaction. Recent work shows that, of the 60 cannabinoid molecules in the plant, delta-9-tetrahydrocannibinol is responsible for the central effects of cannabis. Here we aimed to investigate, in more detail, the psychological effects of synthetic intravenous THC in healthy subjects. Over 2 experimental sessions, participants (N=22) were administered 2.5mg IV THC or placebo under randomised, double-blind conditions. Psychological reactions were assessed using standard rating instruments and a battery of cognitive tests was completed.

Following THC, there was a significant increase in self-rated and observer-rated positive psychotic symptoms which were highly correlated (r=0.62, p=0.001).Phenomena centered on de-synchronisation of self-agency (ipseity disturbance) and hypersalience/paranoia. Participants also reported a significant increase in negative symptomatology under THC conditions, which was not explained by sedation. Finally, working memory/executive functioning was markedly and consistently impaired by THC.

Here we provide further evidence that THC can elicit an acute psychotic reaction in a proportion of healthy subjects. Acute THC-psychosis elicits positive, negative and cognitive symptoms. Compared with other drug models THC recreates symptomatology across 3 major dimensions of schizophrenic psychosis without sedation/clouding of consciousness. Here we also present preliminary evidence that the molecule cannabidiol (CBD) inhibits THC-elicited positive symptoms. Current work in our laboratory is exploring the underlying mechanisms.

http://linkinghub.elsevier.com/retrieve/pii/S0924933809703797?via=sd&cc=y

NOT.


71 posted on 03/05/2012 6:23:25 PM PST by LomanBill (Animals! The DemocRats blew up the windmill with an Acorn!)
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