Mike
In one other case, a prospector had a single shot .22 and a box of shorts. His dog and a griz got into a tangle, and he kept plugging away at the bear’s head with his .22 and shorts.
The bear roared at him at some point, and he popped it through the roof of the mouth into the brain and killed it.
There was also at least one case where a .22 was used to kill and elephant. It was a shot to the big arteries out of the heart. The animal was quietly shot, then the hunters waited several minutes for it to bleed out and topple over. Not exactly a quick stopper!