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Combofix does that. Ran it once but it was the only way to get my computer back. Even the place where I bought it couldn't fix it with my original OS disks. I call combofix the utility of last resort.

One thing people forget to do after getting their machine back to normal is to clean out their system restore and create a new restore point. Some junk can still be hiding in there. I do it occasionally a part of my system maintenance after running all clean up utilities. Makes my drive run a little faster.

For XP;

http://support.microsoft.com/kb/310405

Win 7, Vista

http://www.howtogeek.com/howto/windows-vista/disable-system-restore-in-windows-vista/

Turn restore off, exit process then go back in and turn on. Go into system restore through all programs and create a new restore point. Do not restart before doing this.