We should be so lucky for that to happen.
I'm going to have to be a devil's advocate on this one. If Obama resigns early next year, we may very well be looking at the Hildabeast as president beginning January 2013. I think any GOP candidate will be able to beat Obama; not so sure about Hillary. Most of our NEA-educated moronic voters have completely forgotten about the missing billing records, the rediculous "dodging bullets" in Kosovo lie, and all the other pathetic Bill & Hillary escapades. She'd probably be named as Biden's veep and would accept with his pledge not to oppose her for the 2012 nomination (which he would realize he could not win against her).
A wounded and disgraced Obama is a much more encouraging target for the GOP in 2012. This may, of course, be the very reason why dem party elders may start leaning on him to resign (say, to take some high-level UN post) if his numbers really continue to tank.