Dreyfuss portrayed U.S Vice President Dick Cheney in Oliver Stone’s 2008 George W. Bush bio-pic W.
On February 16, 2006, Dreyfuss spoke at The National Press Club in Washington, D.C. in hopes of prompting a national discussion on impeachment charges against U.S. President George W. Bush.
In November 2009, he said that journalists are the only representatives citizens have left in Washington. “I am going to ask the Republican and Democratic parties for big checks.”