I truly believe that Hillary Clinton will wait until July or August of 2010 to suddenly find something that she requires her to step down from the position of Secretary of State.
She will then wait and see how the 2010 elections go, and if they go very poorly, she will start building her run at unseating Obama as the Democratic nominee for 2012.
And the thing is, he has given her the opportunity to fill in her resume with foreign policy and administrative experience.
If Hillary plays her cards right and goes after BOTH Obama and Pelosi (who polls show is loathed), she'll up her value substantially. At this juncture people are so fed up with the maoist, marxist, socialist agenda of Obama, it should be a breeze for Clinton to usurp him is she is the one in this administration to show patriotism and dignity on behalf of all Americans. She can easily upstage Obama and his advisors on the global front to champion America's interests (instead of the Obama tactic of demeaning them).