by Erowid
| Onset | 20-90 minutes |
| Coming Up | 5-20 minutes |
| Plateau | 2-3 hours |
| Coming Down | 1-2 hours |
| After Effects | 3-24 hours |
Some people are considerably more sensitive to MDMA than others. Be careful if you are using MDMA for the first time or using material of an unknown purity and strength.
- POSITIVE
- extreme mood lift
- increased willingness to communicate
- increase in energy (stimulation)
- ego softening
- feelings of comfort, belonging, and closeness to others
- feelings of love and empathy
- forgiveness
- increased awareness & appreciation of music
- increased awareness of senses. (eating, drinking, smell)
- profound life-changing spiritual experiences
- neurotically based fear dissolution
- sensations bright and intense
- urge to hug and kiss people
NEUTRAL - appetite loss
- visual distortion
- rapid, involuntary eye jiggling (nystagmus)
- mild visual hallucinations (uncommon)
- moderately increased heart rate and blood pressure (increases with dose)
- restlessness, nervousness, shivering
- change in body temperature regulation
- strong desire to do or want more when coming down
NEGATIVE (see the MDMA Side Effects Profile)
(negative side effects increase with higher doses and frequent use)
- inappropriate and/or unintended emotional bonding
- tendency to say things you might feel uncomfortable about later
- mild to extreme jaw clenching (trisma), tongue and cheek chewing, and teeth grinding (bruxia)
- difficulty concentrating & problems with activities requiring linear focus
- short-term memory scramble or loss & confusion
- muscle tension
- erectile disfunction and difficulty reaching orgasm
- increase in body temperature, hyperthermia, dehydration (drink water)
- hyponatremia (don't drink too much water)
- nausea and vomiting
- headaches, dizziness, loss of balance, and vertigo
- post-trip Crash - unpleasantly harsh comedown from the peak effect
- hangover the next day, lasting days to weeks
- mild depression and fatigue for up to a week
- severe depression and/or fatigue (uncommon)
- possible strong urge to repeat the experience, though not physically addictive
- possible psychological crisis requiring hospitalization (psychotic episodes, severe panic attacks, etc) (rare)
- possible liver toxicity (rare)
- possible neurotoxicity (controversial)
- small risk of death. Approximately 2 per 100,000 users have extreme negative reactions resulting in death. (rare)