Aside from the fact that you completely avoided the issue I had raised, such was not the intention of the founding fathers who sought not to have the government as a ultimate determinant of its own power but rather relied upon an underlying concept of natural law to restrain that power.
Needless to say, the fact remains so: the supremacy clause includes all of the constitution and that means amendment 10 as well. Amendment 10 is therefore supreme to any and all federal laws, meaning that any and all federal laws that violate Amendment 10 are by way of the supremacy clause unconstitutional.