[AndrewC]

the genes from that class of organism will be most similar to the genes of animals which most recently diverged from the same line of descent, determined by non genetic evidence such as fossils, morphology, etc..

Well do you consider this comparision of ADH3 proteins as confirmation?

Base ADH3 -- Sea Squirt -- Ciona intestinalis

• Danio rerio Score = 532 bits (1370), Expect = e-150
• Sparus aurata Score = 531 bits (1369), Expect = e-150
• Branchiostoma floridae Score = 524 bits (1349), Expect = e-148
• Gadus morhua Score = 520 bits (1340), Expect = e-146
• Anopheles gambiae str. PEST Score = 520 bits (1338), Expect = e-146
• Indian spiny-tailed lizard Score = 515 bits (1327), Expect = e-145
• Branchiostoma lanceolatum Score = 512 bits (1318), Expect = e-144
• Caenorhabditis elegans Score = 506 bits (1302), Expect = e-142
• Drosophila melanogaster Score = 503 bits (1296), Expect = e-141
• Atlantic hagfish Score = 492 bits (1267), Expect = e-138
• Mus musculus Score = 490 bits (1262), Expect = e-137
• Rattus norvegicus Score = 490 bits (1261), Expect = e-137
• Homo sapiens Score = 488 bits (1256), Expect = e-137
• Equus caballus Score = 484 bits (1247), Expect = e-136
• Oryctolagus cuniculus Score = 481 bits (1238), Expect = e-135
• Octopus vulgaris Score = 476 bits (1226), Expect = e-133
• Shewanella oneidensis MR-1 Score = 451 bits (1160), Expect = e-126
• Microbulbifer degradans 2-40 Score = 447 bits (1151), Expect = e-125
• Yersinia pestis KIM Score = 447 bits (1149), Expect = e-124
• Arabidopsis thaliana Score = 441 bits (1134), Expect = e-123
• Vibrio vulnificus CMCP6 Score = 441 bits (1133), Expect = e-122
• Pisum sativum Score = 439 bits (1128), Expect = e-122
• Vibrio parahaemolyticus Score = 436 bits (1121), Expect = e-121
• Oryza sativa Score = 434 bits (1117), Expect = e-121
• Pseudomonas syringae pv. tomato str. DC3000 Score = 434 bits (1116), Expect = e-120
• Neurospora crassa Score = 432 bits (1111), Expect = e-120
• Zea mays Score = 428 bits (1100), Expect = e-119
• Xanthomonas axonopodis Score = 424 bits (1089), Expect = e-117
• Xanthomonas campestris Score = 422 bits (1085), Expect = e-117

[Right Wing Professor]

You'll have to give me a little more of an explanation than this, and perhaps a source.