Floss-based vaccination targets the gingival sulcus for mucosal and systemic immunization

nature.com ^

[algore]

The oral cavity is an accessible site for vaccination, but its sublingual and buccal sites have limited vaccine uptake.

Here we show that flat tape dental floss can deliver vaccines through the junctional epithelium of the gingival sulcus, exploiting its naturally leaky properties.

Floss-based vaccination delivered protein, inactivated virus, peptide-presenting immunogenic nanoparticles and Messenger RNA.

In mice, gold nanoparticles functionalized with a peptide derived from the ectodomain of the transmembrane matrix 2 protein of human influenza virus stimulated local lymph nodes, increased CD4+ T cells in lymph nodes, lungs and spleen, and boosted antibody-secreting cells in the bone marrow.

Floss-based immunization induced strong and sustained immune activation across multiple organs, robust systemic and mucosal antibody responses, and durable protection against lethal influenza infection, independent of age, food and liquid consumption.

Floss-based vaccination was superior to sublingual and comparable with intranasal vaccination.

In human participants, fluorescent dye delivered via floss picks effectively reached gingival sulcus, supporting clinical feasibility.

These findings establish floss-based vaccination as a simple, needle-free strategy that enhances vaccine delivery and immune activation compared with existing mucosal immunization methods.

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TOPICS: Heated Discussion
KEYWORDS: vaxx

[algore]

They had better leave my toothpicks alone.

[blackdog]

Captain Crunch, with Vax-Berries.

The desire to do this only indicates the sinister and nefarious motives to drive the nightmare. You can only redefine, reshape, and rebrand, really bad ideas for so long before the whole mess comes into a better public focus.

[left that other site]

I’m gonna move to Montana and grow my own Dental Floss.

[blackdog]

"Flu-Tee-Loops", Fortified with 19 different vitamins and mRNA alterations in each serving.

There are many reasons Kelloggs sold the business. Toothpicks was just beta testing #6,429.

[Carry_Okie]

I can see it now: Baking my dental floss.

[rarestia]

Switch to wax-coated silk floss. Much better for you (no microplastics) anyway. Or get a waterpik.

[blackdog]

My wife always suspected tampons, body powder, toothpaste, eye drops, and vitamins, as being the perfect delivery device products. Things that have time and routine uses that are measured and specific, yet without any desire to over-use them.

Condoms, with mRNA lube. I'm sure that's already past the testing phase, too.

[AFB-XYZ]

I’m not paying to read an article that might be just the opinion or the fantasy of \some self-described “expert” or “scientist”.

I’d love to know (1) whether what’s in the excerpt is a “done deal” or just some think tank’s desir3e for the future; (2) If a “done deal”, exactly where it’s being implemented; and (3) What brands of dental floss are NOT affected, and thus still safe to buy.

[jimwatx]

“Floss-based immunization induced strong and sustained immune activation across multiple organs, robust systemic and mucosal antibody responses, and durable protection against lethal influenza infection, independent of age, food and liquid consumption.”
*********************************
The increased mucosal antibody responses means it’s likely more effective against respiratory viruses than conventional vaccine. But I would never take a mRNA “vaccine” of any kind.

[9YearLurker]

Now they’re flossing mouse teeth?!?

“Nature Biomedical Engineeringnature biomedical engineeringhttps://doi.org/10.1038/s41551-025-01451-3ArticleFloss-based vaccination targets the gingival sulcus for mucosal and systemic immunization Rohan S. J. Ingrole 1, Akhilesh Kumar Shakya1, Gaurav Joshi1,2, Chang Hyun Lee1, Lazar D. Nesovic1, Richard W. Compans3 & Harvinder Singh Gill 1,2,4 The oral cavity is an accessible site for vaccination, but its sublingual and buccal sites have limited vaccine uptake. Here we show that flat tape dental floss can deliver vaccines through the junctional epithelium of the gingival sulcus, exploiting its naturally leaky properties. Floss-based vaccination delivered protein, inactivated virus, peptide-presenting immunogenic nanoparticles and messenger RNA. In mice, gold nanoparticles functionalized with a peptide derived from the ectodomain of the transmembrane matrix 2 protein of human influenza virus stimulated local lymph nodes, increased CD4+T cells in lymph nodes, lungs and spleen, and boosted antibody-secreting cells in the bone marrow.”

[Carry_Okie]

Condoms, with mRNA lube. I'm sure that's already past the testing phase, too.

This is ugly.

Time for a law. If these idiots want to get into drug delivery, it's time for the FDA to come down on them with labeling requirements. I'm half amazed their insurers aren't putting the kibosh to it.

[RideForever]

Barbara O’Neil suggest a tablespoon of coconut oil, swished around in your mouth for 10 minutes. 30 seconds swish, 30 seconds expel in garbage (keep out of plumbing cuz it hardens), 10x.

[blackdog]

Most of these present day virus research projects have a DARPA origin or stewardship, and as such, things like consequences are acceptable, if not, intended to be anyway.

It's the hand-off and alliances between the NIH, CDC, WHO, and WEF, that intersect with the facades of public trust necessary to deliver the "thing" developed to a consumer population.

[linMcHlp]

Floss-based "vaccination" reactions:

• gum disease
• gum inflamation
• loose teeth
• lost teeth
• more visits to the dentist office
• CNN / W'Post / NYT and California blaming Trump

Might convince more peope to NOT floss their teeth?

PS. Did "9 out of 10 dentists, approve?"

[dljordan]

These people are insane.