The Founders recognized that people should live their lives largely free of federal interference. This is not to say that the Founders intended or imagined a libertine America. On the contrary, they envisioned an America with vibrant religious, family, social, and civic institutions that would shape a moral nation. They understood that strong private institutions, so important in a free and just society, could not coexist with a strong, centralized government.-Rep. Ron Paul (R-TX)
Gambling laws.
Gambling is not an immoral activity.
Granted, but the Founders also gave great latitude to the states. Prior to the incorporation of (some of) the federal Bill of Rights, states were pretty much free to do what they wanted (limited, of course, by their own state constitutions).
I believe the 14th amendment took away more state autonomy than the Commerce Clause ever will.
"Gambling is not an immoral activity."
Neither is eating or drinking alcohol. It can be immoral if done to excess.