No. An amendment was desired, not required.
"it strongly implies that they have no such authority over drugs, firearms, polar fleece ..."
The Harrison Narcotics Tax Act was passed in 1914.
That didn't come from the commerce clause. Look two clauses above on your pocket Constitution.
The Harrison Narcotics Tax Act imposed a tax on distribution of certain drugs, and imposed certain restrictions on those paying the tax.
In this manner, it operated similarly to the $200 machine gun tax imposed by the National Firearms Act of 1934, which regulated machineguns under the fig-leaf of purportedly being a revenue measure.
In neither case the the federal government assert an independent authority to impose restrictions on the items -- instead they disguised what they were doing under another heading