If someone says they can control the dosage better by smoking, they're either stoned or ignorant. If you had to take a 5 mg dose of widgetol and your choices were to smoke a 'rolled cigarette' of widget leaf containing 3-10 mg of widgetol depending on where it grew, how wet the growing season was, and how long ago it was harvested or 2.5 mg tablets of measured and processed widgetol, which would you use?
As far as impurities, smoked marijuana not only delivers a couple carcinogens but has many other physiologically active substances. That's why early studies had difficulties. It was hard to determine which cannabinoid was the one causing the desired effect and which were causing the side effects - like pain relief versus mental disorientation. With an isolated cannabinoid or a synthetic, the action becomes specific and side effects can be minimized.
If someone says they can control the dosage better by smoking, they're either stoned or ignorant. If you had to take a 5 mg dose of widgetol and your choices were to smoke a 'rolled cigarette' of widget leaf containing 3-10 mg of widgetol depending on where it grew, how wet the growing season was, and how long ago it was harvested or 2.5 mg tablets of measured and processed widgetol, which would you use?
As far as impurities, smoked marijuana not only delivers a couple carcinogens but has many other physiologically active substances. That's why early studies had difficulties. It was hard to determine which cannabinoid was the one causing the desired effect and which were causing the side effects - like pain relief versus mental disorientation. With an isolated cannabinoid or a synthetic, the action becomes specific and side effects can be minimized.