First off, I don’t recommend carrying a defensive handgun
in a pocket, but in a holster, same place, every day, dressing for concealment, and training frequently to draw and fire to a high degree of proficiency. Like your life depended on it.
If you insist upon a wheel gun the Charter Arms “Bulldog”
with a bobbed hammer, 3” barrel, in .44 SPECIAL is THE way to go...no two ways about it.