I would expect the Apixaban to be a problem for someone who has had two intercranial hemorrhages.
“The most noteworthy health incident that Vice President Biden has experienced was his intracranial hemorrhage from a cerebral aneurysm in 1988. His aneurysm was repaired surgically,” wrote Dr. Kevin O’Connor, an associate professor of medicine and the director of executive medicine at George Washington University, who treated Biden at the time.
“During this workup, his team discovered a second aneurysm, which had not bled. This was also treated. He has never had any recurrences of any aneurysms.