150 mg of melatonin a day and 6,000 mg of flush niacin a day is crazy, without better documentation than what you provided.
That's because most view melatonin as a sleep aid. This has nothing to do with that. Yes, it could use more sauce. The papers are scattered and this is coming from an epidemiologist who has put it all together. He provides sources, but I simply have not put them all together yet. If you'd like to point out any errors, I'm listening. Further, I did not translate from a foreign tongue. I edited his English explanation to be more easily read. Punctuation is not Dr. Kats strong point.
Moar documentation:
Dr Kats NIATONIN— Podcast and Transcript (early draft of the protocol - it has changed a bit plus language warning)
https://otter.ai/u/-Wx6-rY8F9tFqiaYtLfNuP4vBG4?fbclid=IwAR2UyZaywMx6TUmusG-CziIf86e1TDQKULZ8wfJKZ2z4lVULmBUtikn9J6A
Metal chelating and hydrogen peroxide scavenging effects of melatonin
https://pubmed.ncbi.nlm.nih.gov/12662350/
Melatonin mitigates cadmium phytotoxicity through modulation of phytochelatins biosynthesis, vacuolar sequestration, and antioxidant potential in Solanum lycopersicum L
https://www.frontiersin.org/articles/10.3389/fpls.2015.00601/full
Melatonin prevents oxidative stress resulting from iron and erythropoietin administration
https://pubmed.ncbi.nlm.nih.gov/11273875/
Nicotinic acid inhibits NLRP3 inflammasome activation via SIRT1 in vascular endothelial cells
https://pubmed.ncbi.nlm.nih.gov/27614220/
Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin
https://pubmed.ncbi.nlm.nih.gov/19781706/
Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization
https://www.nature.com/articles/srep42279?fbclid=IwAR2oV8auLcaByyASFzNwf3P40qgiF31OWEQwqiPd1Ywgnwtosaf3ZrlTSWw
Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein A-I in HepG2 cells
https://www.jlr.org/article/S0022-2275(20)39224-5/fulltext
Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment
-Essentially, according to the ACTUAL health science, prion disease / neurodegeneration = accumulative lack of niacin (and melatonin) over the life course... and so can be prevented—as well as even reversed—simply by repleting niatonin.
https://pubmed.ncbi.nlm.nih.gov/25678560/
ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders
https://portlandpress.com/clinsci/article-abstract/135/3/535/227747/ACE2-and-energy-metabolism-the-connection-between?redirectedFrom=fulltext
IMPORTANT —> Niacin fine-tunes energy homeostasis through canonical GPR109A signaling
https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.201801951R
Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-021-00915-3
ACE2 and gut amino acid transport.
https://www.unboundmedicine.com/medline/citation/33140827/ACE2_and_gut_amino_acid_transport?fbclid=IwAR2jDQTmbW_QWnJyVFT_AC-LXqA0WI2I-i-W3yQ4RJ39yR0l8lH5ExCxAno
Niacin attenuates the production of pro-inflammatory cytokines in LPS-induced mouse alveolar macrophages by HCA2 dependent mechanisms
https://pubmed.ncbi.nlm.nih.gov/25038318/
Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization
https://www.nature.com/articles/srep42279
Role of HCA2 in Regulating Intestinal Homeostasis and Suppressing Colon Carcinogenesis
https://www.frontiersin.org/articles/10.3389/fimmu.2021.606384/full
The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages
https://www.nature.com/articles/ncomms4944
NAC Bonus materials
N-acetylcysteine as a potential treatment for COVID-19
https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2020-0074
N-acetyl cysteine: A tool to perturb SARS-CoV-2 spike protein conformation
https://chemrxiv.org/engage/chemrxiv/article-details/60c753ec4c89190f3bad43ca
N-Acetylcysteine Reverses Anxiety and Oxidative Damage Induced by Unpredictable Chronic Stress in Zebrafish
https://pubmed.ncbi.nlm.nih.gov/29876880/
Combinatorial glucose, nicotinic acid and N-acetylcysteine therapy has synergistic effect in preclinical C. elegans and zebrafish models of mitochondrial complex I disease
https://academic.oup.com/hmg/article/30/7/536/6153421