>How does the whole NIATONIN thing work?

Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.

The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.

The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.

The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.

THE DR KATS LAYMAN'S VERSION
(edited for clarity - English is not his first language)

Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.

These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.

Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.

They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.

Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/

The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.

The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.

Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.

As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.

Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.

This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.

Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.

So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).

It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.

Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/

What To Buy

DOSING

This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.

HOW TO FLOW CHART

That was an early take when he had an "Ah ha" moment. There were other things in that protocol like NAC. Although still recommended, only the NIATONIN is necessary.

OK, so maybe transcribing the video wasn't such a good idea, if it's already obsolete by now. But here's what I have:

Starting at 29 minutes, ending at one hour of the three hour video:

The virus tries to sneak in and replicate off of accumulated cholesterol and macrophages in the body. If you’re eating crappy food or even exercising too much, you can under-accumulate energy and get a redox inflammation, where you’re not providing enough calories to maintain a thermodynamic balance. There are so many ways for cholesterol to accumulate. People can look healthy and yet have unhealthy lipids accumulating in the cells.

Usually you want kind of a well-oiled machine. When cholesterol starts to accumulate, the lipoproteins, the HDL — they develop originally in the liver — you want to get the cholesterol out of the liver and into the cells. Immunity requires the cholesterol transport system — between liver and cells — to work effectively, in thermodynamic steady state. If cholesterol accumulates (usually through cardio metabolic pathology, overeating, sedentary lifestyle) the HDL tries to put the cholesterol into the tissues rather than in the blood, where it will cause atherosclerosis, stiffening arteries, leading to CAD or stroke. SARS-COVID-2 … SRB1 receptors (or gene CD36) are supposed to be handling cholesterol but if there’s too much cholesterol in the blood so it has to be pushed into the tissues and macrophages, there’s higher expression of SRB1, which is the coreceptor for ACE2. Less HDL is produced in the liver, the cholesterol is really gooey, the HDL is of poor quality, so lipid deposits turn into lipid racks (?). This over expression of SRB1 and ACE2 (the inflammation receptor, SRB1 signals that there’s too much cholesterol) is the advantaged entry point for the SARS-COVID-2 virus, which will use the accumulated cholesterol to invade the mitochondria and steal the energy for its own replication. It’s the first virus ever for which the Warburg effect is necessary and sufficient.

This causes hypoxia — your cells no longer get the oxygen from the mitochondria. You body tries to get the cholesterol out, and this just fuels the fire more, leading to cytokine storm, organ damage, complete respiratory distress, lung damage, organ failure, and death.

Instead of shots, the niacin is a causal treatment. The more continued niacin supplementation, e.g., a 500 mg flush, … the niacin is attracted to the inflammation (which everyone has). Serotonin is released from mast cells. Prostaglandin D2 (biomarker of aging) is released from mast cells —flush niacin gets rid of that, too. You turn red, your capillaries are opening up, you’re literally excreting out inflammation, there’s a heart rate increase, a tingly inverted sunburn. It’s different for COVID long-haulers, whose bodies are being “hexed”. Their bodies are so biochemically and metabolically disoriented, they have to build up and get used to it.

For prevention you can build up you niacin dose. Some people need a whole gram: if you have high cholesterol, low HDL, cardio metabolic disease risk factors, Generally 500-1500 mg for adults, half that for teenagers, and half that again for “toddlers”.

The longer you persist with niacin, the more lipolysis you inhibit. You’re eliminating the collection of esterified cholesterol into your macrophages and this in turn stabilizes all your lipids. HDL goes up, more is produced in the liver, your lipid cycle is stabilized, with positive effects on immunity. The SRB1 receptors (and CD36 gene) are no longer over-expressed from pushing cholesterol into the tissues. You’re making it nearly impossible for the SARS-COVID-2 virus to invade. If people get the right amount of niacin, COVID will be eradicated — and they know this.

If you get COVID, the flush niacin brings back your breathing, reverts the lung injury. There’s no need for a respirator — the respirator is just fueling the fire. At any stage of the disease, niacin is the best option for rapid recovery (1.3 median days). You’re destroying the opportunity for the virus to invade initially or to replicate if it’s already there. Better than ivermectin. In cytokine storm, 500-1000 mg right away. Your body will take it brilliantly — the SRB1 receptors are thirsting for niacin.

Q: how often to “flush”?

Each dose is 500-1500 mg. In acute COVID, 2-3 times/day. Some people with serious arthritis or deep depression or schizophrenia take 2 g, 10x/day. For general maintenance, our diets only contain about 20 mg/day, so not enough to produce flush response. Even 70 mg extra will half the rate of cognitive decline, or half the degeneration of gray tissue matter in the brain, or severely mitigate HIV symptoms.

They usually give the high doses to people with high cholesterol, low HDL — to stabilize lipids and lipid transport. They’ve known about niacin for hundreds of years, and have continued to suppress it. They don’t want us to know about its therapeutic power. The dosage depends on the individual. You can start with 50-100 mg and work up, and get used to the flush. When you take the niacin, simultaneously take the same dose of niacinamide. The niacinamide provides synergy to keep the integrity of the mitochondria, and this is with SIRTs (?), park (?) mechanisms, and epigenetic methylation, DNA regulation around the cell. I would start with the flush, for anyone but long-haulers. Most will need the niacinamide along with the flush niacin to address the whole tryptophan oxidation depletion NAD (?) rewiring.

For general health maintenance/prophylactic use, start with with flush niacin and incorporate the nicotinamide (= niacinamide), too. Get a good B-complex, too, to take once a day. You want methyl Bs, because the niacin will eat up methyl groups. A good methyl B complex … Measure with a high-precision scale. Mix it all together and take at once. The niacins are the bioenergetic regulators of immunity, health, of epigenetic. These are ancient amino acids that our foods don’t supply enough of: anti-inflammatory, immunity modulators, and anti-viral — and also just to maintain health. For general maintenance and good health you don’t have to go overboard. Some researchers, before interviews, will take two grams. The first few times your body will react strongly to it, but the novelty wears off. Your body gets used to it, you’ll come to enjoy it.

You want to replenish your B’s. We’re really deficient in all nutrients. But the B’s are essential to citric acid cycles, cellular respiration, oxidative phosphorylation, mitochondrial integrity, energy metabolism. They all work in unison, but the niacin flush is like a gift to us, to use. You need that dump to communicate with your liver to address the inflammation, to fine-tune the balance of free radicals and potential energy in your mitochondria. Also, NAC is getting a lot of press because Amazon is refusing to sell it. You can still get it online. NAC, along with NAD/NADH, is a biomarker of the biointegrity and dynamic balance you want to maintain. The other side of the coin is anti-oxidation, essentially hydrogen peroxide and super free radical balance. Another way to look at it is glutathione/glutamine equilibrium. And ideally, during inflammatory syndromes and progressions of pathologies involving inflammation, whether chronic or acute, or infections as in COVID, your glutathione is being depleted. Glutathione is all through your body, especially in your brain. U Penn Medical School just published this great study where they showed that flush niacin and NAC preserve the mitochondrial integrity and revert from mitochondrial complex-one disease, which is kind of like the early acute stages of COVID, when the virus is trying to take hostage of your mitochondria and suck up all your energy. It’s kind of like the Warburg effect, where your body’s cells try to make energy through glycolysis around the cytoplasm. So we’re trying (?) to quickly flush out the virus by inhibiting these TPC channels that are connected to potential energy which is expressed through NAADP that has cross-talk communications through the recruitment of T-cells. The T-cells engulf foreign invaders and pathogens, kill it, and excrete it out of your body. NAC promotes that. There’s a caveat. People who have gout/high uric acid won’t react to the flush niacin, but the NAC will get rid of the gout so you can use flush niacin. Gout is where glutamates are too high in comparison to glutathione. NAC, along with magnesium glycerinate and zinc, will promote glutathione. With infection and inflammation your glutathione is being depleted, and the NAC is the most efficient promoter of glutathione.

Glutathione/glutamate is tied up with hydrogen peroxide/superoxide, they are correlated, side-by-side, working together in this bioenergetic balance. It’s another chemical that’s involved in this process. So you’re when you’re getting COVID, your NAD is depleted, you have inflammation ensuing as the virus replicates, you feel worse and worse, organs are damaged, the NAC and niacin have this synergy. The NAC will address the glutathione depletion, and the niacin — along with niacinamide — support mitochondrial integrity and energy metabolism. Take flush niacin/NAC/niacinamide in equal-molar ratio. Niacin (at 123) and niacinamide (at 122) have about the same molar mass. NAC has a slightly higher mass (at 162), so for every gram of niacin and niacinamide, do 1.33 grams of NAC. The NAC provides further synergy and it promotes glutathione, provides anti-oxidation, you’re going to recover more quickly, For health maintenance you’ll be healthier in general. You don’t have to incorporate as much NAC as the niacins. With the B’s, I like to do a good methyl-B complex at least once a day. I’ll take everything you can take together, and I’ll take it after food. You can take it on an empty stomach, but the human growth hormone is acutely spiked, and you don’t want to mess with that too much. Some people like it. If you’re sick it doesn’t have to be after food. I’ll take one of these B-methyl complexes and I’ll also take TMG or tri-methyl-glycine. This helps with balanced methylation — it provides methyl donors and keeps the one carbon cycle processing homeostatically. Along with selenium (?). This TMG converts homocysteine into methanine, which allows for the NAD cycle to be better regulated and fine-tuned, and in order to keep the whole cellular respiration metabolism going.

Vitamin C is another complementary factor for anti-oxidation (see Linus Pauling’s work/Nobel prizes, and Hoffer). They were the Einstein and Bohr of orthomolecular medicine. Pauling and Hoffer eventually united. Get the pure powder for vitamin C and dissolve it in water. You can take a lot of vitamin C — you don’t need too much, but 7 grams at a time with flush niacin can do wonders (along with NAC and niacinamide) for overnight recovery. Vitamin C, you should take every day. If you take those things I mentioned for prophylactic health maintenance, you’ll never get COVID.

People don’t understand the power of niacin, nutrients and a healthy lifestyle, and maintenance of good health behaviors, exercise. They don’t understand that this stuff [pointing to the supplements] promotes that, and has unsurpassed therapeutic powers and anti-viral powers, its intrinsic role in immunity, its anti-inflammatory capacity. There’s an inflammation axis, an oxidation axis, a viral axis, and an immunity axis for niacin — and people still aren’t talking about it.

Since I started reporting all this to UNC, to Ralph Baric himself [head of COVID research at UNC], to my advisor, to the Dean of the School of Public Health, to the Dean of the Medical School, to the Dean of the Pharmacy School, to Gilead, to Glaxos-Smith-Kline, I realized that they’re making a fake niacin, Remdesivir, that’s kind of an analog to niacinamide, they don’t want to hear that I just foiled their whole plot. And this was preliminary, while I was still theorizing. They ignored it and tried to suppress me. I’m surprised they didn’t kill me. If I was them I would have killed me. Their COVID would be going a lot better for them now.

Ending at 1 hour, 32 seconds.

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