Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
The video chat didn’t happen this afternoon. Dmitry blamed it on his internet connection — he hit his data limit or something.
Nothing, but if I want to get up to date with Kats I'mma run through my pile before I switch to new protocol.
L-Serine never goes out of style.
Dana, [Mar 19, 2022 at 2:02:19 PM]:
Hey everyone! I tried searching for anything on this subject throughout the group chat but it's a lot to sift through.... Just taking niacin without anything else can cause glucose levels to rise, correct? My dad just went to the doctor to get his levels checked and all of a sudden his glucose levels are high and the only thing he has really changed is that he started taking niacin but without R-ALA, melatonin, or anything else that we have tried in here. He is being dramatic and says he is quitting niacin for good *eye roll*. Can someone give me and explanation of this so I can help him understand? Thanks in advance!
Heidi, [Mar 19, 2022 at 2:06:38 PM]:
Hi Dana, I believe the answer lies in the reply I got from people after asking how long I should wait to eat after taking Niacin:
"Actually it’s a good question. Since we take the serine and niacin 1/2 hour after a big meal, it’s good to avoid carbs especially and probably most food until your next meal at least seven hours later.
The niacin, among many other good things that it does, primes your body to store carbohydrates as fat - you basically become temporally, insulin resistant. This kicks in about two hours after the niacin and last for about six hours after that so it’s good to space the meals out and avoid snacking between meals while on niacin.
Finally, if you are going to eat a carb snack, do it within two hours of taking the niacin as in this period you are temporally in a good carbohydrate - insulin sensitive mode."
'This exactly. The 3 to 6 hour period ketones become temporarily elevated as you switch to temporary fat metabolism. If you're eating during that window it will cause elevated blood sugar, your body isnt primed for carb metabolism."
So, my takeaway from that would be to do it after your last meal of the day but while it's still daylight, as DK is now suggesting.
Based on Dmitry’s work and my results, several friends in my essential oils community have decided to start niacin. The first one, a 70ish female, started about 10 days ago. After seven days, she noticed something surprising.
To describe it, I had to learn some new terminology. The joint between the hand and a finger is called the metacarpophalangeal joint. Let’s call it the M-joint.
For years she had an arthritic (or rheumatoid?) swelling on the M-joint of the index finger on her right hand, making it about twice its normal size. She’s a busy computer and smartphone user, and she would frequently take a day off from technology because of pain in this joint.
After seven days of niacin + R-ALA, the joint was pain-free and reduced practically to normal size. She’s a convert.
Today she took L-serine for the first time and was happy all morning. A double convert.
Her ex-husband, a bonafide rock star who’s been playing guitar for 60 years and now has arthritic hands, is next in line. If niacin succeeds with him, I expect it to spread through the boomer rock community.
As you probably already know, Dmitry has added another element into the mix, L-Methionine. This is supposed to be used early on in the protocol for people who are suffering symptoms of the virus or vaxx, but only temporarily.
I went through the thread the other day. The focus seems to be on vax injury. I ain’t worried about that. In fact we switched back to mellie and niacin since we finally ran out of sericin.
True, the methionine is only for those who have virus or vax symptoms, but Dmitry seems to think that lipoic acid is the bomb, for everybody.
People are saying that L-Methionine may be even smellier than butyrate — and that’s saying something. I’ll let you know.
At least it’s really cheap — about the cheapest of all of Dmitry’s recommendations.
Yesterday I took the ASEA plunge. I need to find out what it’s about. I delayed for a couple of reasons. A big one is the price. For anyone over 50 (I’m 67), they recommend taking 8 oz/day — and it’s about a dollar per ounce. Ouch! The second reason for delay was the fact that ASEA is a network marketing company. This is completely ironic because I’m a member of Young Living, which is an iconic network marketer of essential oils. But there it is. I’ve finally passed that hurdle. My ASEA will arrive in a few days. I’ll start up a log for it so I can track what I take and what it does. Y’all will be the first to hear.
At this point, already enjoying blissful acupuncture and L-Serine serenity, I don’t know how much improvement is still possible — but I have to keep trying.
Thanks for the update.
My brother has an update, too, even better than his 20-year bald spot growing back in. He saw his ophthalmologist today and she told him his retina looks as good as new — this after losing 25% of the visual field in one eye, also due to radiation therapy 20 years ago.
Ping to the newest protocol.
I’ve completely given up trying to follow Dmitry or these ever-changing protocols, and don’t even know what all that recent stuff is. I’ve also fallen off the niacin wagon, and feel little incentive to get back on it, due to my disenchantment over its failure to mitigate my latest and worst-ever bout with allergies and sinus problems even in the slightest while I was still megadosing it. I tried taking some the other day, and of course flushed big-time, and there was nothing worse than having my whole body itching for 90 minutes while I was simultaneously busy hacking up mucus. Nuts.
Well you certainly gave it the old college try.
Yeah, I know, right? I consumed damn near a whole kilo of the stuff since September... LOL
I've done more than that and it's been a great inflammation free ride.
Dmitry’s channels:
Telegram: http://t.me/HOM3OSTASIS
Telegram testimonials: http://t.me/HOM3OSTASIStestimonials
New website/social media site: http://hom3ostasis.com ($10 basic membership, $25 and $50 premium memberships.
Niacin surprises (shared by Dmitry based on user reports): the niacin protocol has relieved multiple sclerosis (MS) and Lyme disease in a matter of days.
New addition today: biotin. Dmitry has been pulling back on B vitamins, mostly because almost all B complexes have nasty niacinamide in them. He now thinks biotin and some other Bs need to be included.
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