>How does the whole NIATONIN thing work?

Telegram and FR | September 9, 2021 | Dr. Dmitry Kats (interpreted)

[numberonepal]

He he. I thought a stone was 8lbs.

[numberonepal]

UPDATED PROTOCOL

2x daily for 125-190 lb (56-86 kg) adults;
if outside range like kid or heavy, then your
dose = (mass / 160 lb [73 kg]) * below listed doses

BEST AFTER MEALS (lunch, dinner):

3.6-5.0 g BUTYRATE - https://www.amazon.com/BodyBio-Sodium-Butyrate-Vegetarian-Capsules/dp/B0058A9SF0 - ^3.6 g = 6 capsules: reduce 1-2 caps per dose if loose stools and/or tiredness arise beyond 1st few days (signals butyrate / gut microbial + melatonin restoring). If in immunosuppressive state (e.g. long hauler): butyrate can arouse needed, previously suppressed pro-inflammatory response (T-cell differentiation), evoking acute fever. Once this occurs, take more niacin (at least 1 g) & lower butyrate dose subsequently by 2 caps

+

800-1600 mg Taurine (higher for dinner) - https://purebulk.com/products/taurine?variant=14294881959985&&sca_ref=1004090.8JspdBHd04

+

200-300 mcg Selenium (lunch and/or dinner) - https://www.amazon.com/BodyBio-Selenium-Liquid-Mineral-2oz/dp/B00N24J2LO

+

Turmeric/Curcumin (1-2 caps; higher in day) - https://www.amazon.com/NatureWise-Curcuminoids-Absorption-BioPerine-Inflammation/dp/B01BMDAVIY

+

600 mg Acetyl L-Carnitine (ALCAR) if it helps, then lunch/day - https://purebulk.com/products/alcar-acetyl-l-carnitine?variant=14294904700977&&sca_ref=1004090.8JspdBHd04

… wait 20-30 minutes…

1-3 g NIACIN (per need/comfort) - https://purebulk.com/products/niacin-vitamin-b3-immediate-release?variant=14294913515569&&sca_ref=1004090.8JspdBHd04 (for quicker delivery: https://shareasale.com/r.cfm?b=772960&u=2941673&m=53326&urllink=&afftrack= ) - start @ 500 mg if 1st time & not emergency (don’t fear flush; try to get to >=1 g doses ASAP)

BEST PRODUCTS = PUREBULK ^ International ordering (DHL ship). Use code DMITRYKATS for 10% off / BULKSUPPLEMENTS for FAST ORDER here: https://shareasale.com/r.cfm?b=602574&u=2941673&m=53326&urllink=&afftrack=

—

COFACTORS:

- (Methyl-) B Complex (niacinamide aka nicotinamide as only listed Vit B3 but not >50 mg); 1x/day (or every other day) - https://www.amazon.com/Designs-Health-B-Supreme-Vitamin-Capsules/dp/B002MAT56G

- Real Vit C (not straight ascorbic acid but from fruit/natural source); 1-2x a day dose right after niacin (and/or fruits/juice) - https://www.amazon.com/INNATE-Response-Formulas-Vitamin-Effective/dp/B000JM7K52

- N-Acetyl Cysteine (NAC); if it helps, for recovery, try 1-2x a day right after niacin (limit 2 g total daily… if not, you can drop) - https://purebulk.com/products/n-acetyl-l-cysteine-nac?variant=14294856171569&&sca_ref=1004090.8JspdBHd04

- Grass-fed Beef Liver (1-3 capsules post-meals) - https://www.amazon.com/Ancestral-Supplements-Grass-Liver-Desiccated/dp/B01MSBZYQW

——

AUXILIARY (BUT ALL OF THESE CAN BE VERY HELPFUL):
- Vit E (mixed tocopherols; 1-2 x daily) - https://www.amazon.com/365-Everyday-Value-Vitamin-200/dp/B074KKKMBB
- Phospholipid Complex (2 caps w/ butyrate) - https://www.amazon.com/BodyBio-Phosphatidylcholine-Phospholipid-Complex-Softgels/dp/B00U0RR4O8
- Trimethylglycine (TMG) aka betaine (if homocysteine is high) - https://www.amazon.com/Allergy-Research-Group-TMG-Trimethylglycine/dp/B000GU8SC6
- Colostrum (1-3 caps post-meals) - https://www.amazon.com/Ancestral-Supplements-Grass-Fed-Colostrum/dp/B07NKBD9LF
- Electrolyte Hydration - https://www.amazon.com/BodyBio-Lyte-Electrolyte-Magnesium-Dehydration/dp/B083ZJ48FG
- Chromium (especially w/ niacin) - https://www.amazon.com/BodyBio-Chromium-Liquid-Mineral-2oz/dp/B075X2Z3P5

—

It’s still NIATONIN but KEY is restoration of internal body clock / circadian aka CLOCK-regulated melatonin, by restoring its synchronization w/ gut microbial w/ butyrate (+ taurine, selenium, turmeric/curcumin, ALCAR (some may not need ALCAR or too much selenium)), whilst hitting w/ niacin.

Lower dosing to comfort as you heal. Once restored, keep niacin around 500 mg- 1 g+ doses to comfort. Some butyrate before here & there.

[Mama Shawna]

The telegram group has been fantastic! Have spent a lot of time there in the last week. If anyone wants more/detailed info on this protocol I highly recommend it.

[Mr. K]

I’m curious if anyone else here has had a reaction to turmeric?

Are used to take a lot of it no problem, but lately whenever I take it I get some swelling on the side of my face by my ear.

[numberonepal]

I get some swelling on the side of my face by my ear.

I've never heard of that side effect, but it might be inflammation getting out.

[numberonepal]

They made me an admin. IF there are any questions, let me know.

[AZLiberty]

They made me an admin.

In the Dr. Kats world, does that make you a kitten?

[TruthWillWin]

I’m curious if anyone else here has had a reaction to turmeric?

Yes, tried taking it a few years ago, gave me diarrhea.

[AZLiberty]

My GABA and theanine arrived today.

Doses: GABA 500 mg, theanine 400 mg?

I know I’m supposed to suspend the niacin therapy. Any other tips? Is there another Telegram channel for GABA?

[numberonepal]

Don’t know. Gaba is gone from the protocol. I think that was to help with the high doses of mellie for long covid folks. Seems so long ago.

[AZLiberty]

What I read about GABA is that it’s a natural anti-anxiety supplement. Niatonin is a physical reset for the body, and GABA may be its emotional counterpart.

The GABA/theanine dose recommended (and then disappeared) by Dmitry is double the usual recommendation.

I’ve been on GABA (and off niacin) since yesterday morning. I do feel a little more chill than usual, and I’m actually glad to take a respite from niacin. Niacin has been generally good for me (reduced weight, cholesterol, and body odor), but while on niacin I was feeling a distinct but indescribable “pressure” that was relieved by the switch to GABA. I’m sure I’ll switch back, but I’ll try the chill thrill for a while.

I did acupuncture-on-GABA today. I did have a nice acu-nap after needle insertion, but only brief glimpses of the bliss phenomenon after the nap. My body was telling me to get back on the niacin if I wanted the real thing.

[numberonepal]

Excellent report. Thank you.

[numberonepal]

PROTOCOL (educational purposes only)

Energy metabolism homeostasis, i.e. health & functioning, or as characterized under an immunological lense as immune regulation (in synchronization w/ CLOCK-regulated melatonin metabolism), can be represented through homeostatic expression of the GPR109A receptor, notably in the intestinal epithelial barrier. GPR109A regulation rests upon mitochondria maintaining steady state flux of acetylCoA into the TCA Cycle (reduction of NAD+ to NADH) and oxidative phosphorylation thereafter (to make ATP). Typically, cellular respiration proceeds as fueled by glucose to fill energy requirements along the way. In colonocytes, this energy requirement is met most favorably by butyrate, which becomes in higher demand (& depletes) as inflammation overaccumulates: https://twitter.com/ButyrateBrett/status/1459418243827965952

2x daily for 125-190 lb (56-86 kg);
if outside range like kid or heavy, then:
dose = (mass / 160 lb [73 kg]) * below doses

EACH DOSE IS BEST AFTER MEALS (lunch+dinner; so 2 doses daily)

HIGHER the level of gut dysbiosis (“leaky gut”) / immune dysregulation / metabolic dysfunction, HIGHER the dose of butyrate
1.2-10.8 g BUTYRATE (as butyric acid), which corresponds to, for each dose, 2-18 capsules of: https://www.amazon.com/BodyBio-Sodium-Butyrate-Vegetarian-Capsules/dp/B0058A9SF0, or if blood pressure is high: https://www.amazon.com/BodyBio-Butyrate-Magnesium-Vegetarian-Capsules/dp/B0016NHCGA?th=1
*Full recovery may require reaching (ideal to ASAP) whatever the min. dose of butyrate is to meet the aforementioned energy requirement (better to over- rather than under-shoot the dose)

[+ OPTIONAL; start w/o, add each 1 at-a-time in the following order:

800-1600 mg Taurine (higher for dinner) - https://purebulk.com/products/taurine?variant=14294881959985&&sca_ref=1004090.8JspdBHd04

+

200-300 mcg Selenium (lunch &/or dinner) - https://www.amazon.com/BodyBio-Selenium-Liquid-Mineral-2oz/dp/B00N24J2LO

+

Turmeric/Curcumin (1-2 caps/1x daily) - https://www.amazon.com/NatureWise-Curcuminoids-Absorption-BioPerine-Inflammation/dp/B01BMDAVIY]

.. WAIT 5-30 min ..

0.5-3 g NIACIN (veg caps or powder) - https://purebulk.com/products/niacin-vitamin-b3-immediate-release?variant=14294913515569&&sca_ref=1004090.8JspdBHd04 (for quicker delivery: https://shareasale.com/r.cfm?b=772960&u=2941673&m=53326&urllink=&afftrack= ) - try to start @ 500 mg dose (250 mg if sensitive), but work up fast; flush is milder w/ butyrate & quickly goes away w/ continued dosing of niacin (especially upping dose)

PUREBULK: International ordering (DHL ship). DMITRYKATS code for 10% off / BULKSUPPLEMENTS for FAST ORDER: https://shareasale.com/r.cfm?b=602574&u=2941673&m=53326&urllink=&afftrack=

—

COFACTORS

- (Methyl-) B Complex (niacinamide aka nicotinamide as only listed Vitamin B3 but not >50 mg); 1x/day (or every other day) - https://www.amazon.com/Designs-Health-B-Supreme-Vitamin-Capsules/dp/B002MAT56G

- Real Vitamin C (from a fruit/natural source); 400 mg (after niacin) 1x/day &/or fruit/juice - https://www.amazon.com/INNATE-Response-Formulas-Vitamin-Effective/dp/B000JM7K52

—

AUXILIARY (BUT EACH ONE CAN BE VERY HELPFUL)
- Electrolytes (if using sodium & NOT Ca-Mg butyrate) - https://www.amazon.com/BodyBio-Lyte-Electrolyte-Magnesium-Dehydration/dp/B083ZJ48FG
- R-Alpha Lipoic Acid (ALA) - https://purebulk.com/products/alpha-lipoic-acid-r-ala-thioctic-acid
- Chromium (especially w/ niacin) - https://www.amazon.com/BodyBio-Chromium-Liquid-Mineral-2oz/dp/B075X2Z3P5

—

Butyrate (+ niacin) endogenously restores internal body clock/circadian (CLOCK-regulated) melatonin and recoups its synchronization to the gut (taurine, selenium, turmeric/curcumin can each help, albeit may not need or benefit from turmeric/curcumin &/or too much selenium)

Down-titrate butyrate as health restores. Niacin at 0.5-1.5 g doses to comfort & ocassionally some butyrate before = anti-aging

[AZLiberty]

Back on niacin today after three days off. I took two butyrate with breakfast, intending to take the niacin soon after. But something came up so I had to rush off, forgetting to take the niacin. I took butyrate again but didn’t have time for lunch so I just took 1500N with me in the car on the way to a dental appointment for my mother-in-law.

Once in the dental office, the flush took hold. After weeks without a flush, I wondered whether the flush would return after a niacin break. Return it did, gloriously. My past flushes were around the ears and on the forearms. This time the flush was in my legs, all the way up the thighs. It was a luscious warm feeling, sort of like sharing a sleeping bag with one of Bagster’s hotties (I imagine). After a while the heat turned a little prickly, but nothing painful.

I don’t know if the flush was due to the niacin break or to the fact that I did it on an empty stomach. Fun regardless.

[numberonepal]

Here's a calendar I made for someone I'm coaching with the latest protocol. Bear in mind they can't take the creatine, so it is omitted. Otherwise add 4,000 mg Creatine Monohydrate daily - optional, but should help niacin. Click for bigger in new window.

[numberonepal]

Newest protocol.

Below doses for 125-190 lb (56-86 kg); Divide weight by 160 lb [73 kg]), then multiply by below listed doses

30 MIN BEFORE LUNCH & DINNER:

MORE “leaky gut” / immune dysregulation / metabolic dysfunction = HIGHER dose* of butyrate
1-4 g BUTYRATE*
^2-4 teaspoons of:
-https://www.amazon.com/Pure-Encapsulations-SunButyrate-TG-Promote-Function/dp/B07W645FMS
-https://www.amazon.com/gp/aw/d/B08L44JBCD/ref=psdcmw_3773931_t1_B07W645FMS
OR
^2-4 capsules of:
-https://healthygut.com/product/tributyrin-x/
(GUTCLUB15 for $15 off)
-https://www.amazon.com/Healthy-Gut-Tributyrin-X-Generation-Digestion/dp/B09H68YHT2
OR
^2-4 caps of:
-https://www.amazon.com/Butycaps-Tributyrin-Butyric-Capsule-Capsules/dp/B07T31Y45M
OR
^2-4 caps of:
-https://www.amazon.com/Healus-Complete-Supplement-Tributyrin-absorption/dp/B075NTPXY2
-SunButyrate is likely best
-BodyBio works for some but not others
-Taken with blueberries should help
*If recovery doesn’t start ensuing over a few days, consider raising butyrate dose

+

1,000 mg (50 mg elemental) Magnesium (Gluconate preferred) - https://purebulk.com/products/magnesium-gluconate?variant=14294849749041&&sca_ref=1004090.8JspdBHd04

THEN 10 MIN AFTER LUNCH & DINNER:

500-3,000 mg NIACIN*
- https://purebulk.com/products/niacin-vitamin-b3-immediate-release?variant=14294913515569&&sca_ref=1004090.8JspdBHd04 (faster ship: https://shareasale.com/r.cfm?b=772960&u=2941673&m=53326&urllink=&afftrack=)
^PUREBULK = BEST products; choose DHL for international shipping, and DMITRYKATS for 10% off
-if niacin needed ASAP: Whole Foods (FLUSH WARNING on bottle; SOLGAR or 365), Vitamin Shoppe, GNC;
https://www.amazon.com/Solgar-Niacin-Vitamin-Vegetable-Capsules/dp/B0001VUOMM; Health4All, Plain, NutriCost, NOW

*If you can, start at 500 mg/dose (250 mg if sensitive): while restoring butyrate (which gets cells more prepped for niacin), swiftly but comfortably glide up to 750-1,500 mg/dose (start 1,000 mg if emergency); evaluate higher dose to comfort

+

4,000 mg Creatine Monohydrate - optional, but should help niacin
_

COFACTORS

-(Methyl-)B Complex (niacinamide aka nicotinamide as only listed Vit B3 but not >50 mg); after breakfast 1x/day (or every other day) - https://www.amazon.com/Designs-Health-B-Supreme-Vitamin-Capsules/dp/B002MAT56G

-Vit C (fruit/natural source) and/or 1/day of - https://www.amazon.com/INNATE-Response-Formulas-Vitamin-Effective/dp/B000JM7K52

—

Down-titrate butyrate as gut restores. From there, niacin at 750-1,500 mg/1-2 doses/day, with occasionally some butyrate before, offers more than just spike protection.

[numberonepal]

I am doing a nice maintenance dose of 1000mg niacin first thing with NAC (little flush tingle that I like). Then after dinner 7.5mg melatonin, 500mg niacin (for which I made pills) and NAC.

I’m having ragerts about not getting more sun, but I thought I’d have until at least mid November, but nope. I believe we’re in for a humdinger winter. If it’s cold here, the rest of y’all are hurting. It’s already chilly on FL west coast like January (low 50’s - highs in low 60’s brrrr) weather. I had to put on SHOES this morning to walk the animals. It’s freaking me out a little bit.

[Mr. K]

I got a vitamin D sun lamp and I’ve been using that everyday

[numberonepal]

That’s cool. The shortest day of the year is fast approaching, but we still have a couple hours of good UV almost every day. We won’t suffer at these latitudes.

[17strings]

Yeah, here on the SE coast yesterday was the first day I put on jeans (still with sandals, not shoes), but today it’s back to shorts weather again. Short-lived cool spell, this time!

I’ve been rolling merrily along with my 1000mm Niacin 2 or 3 times a day. Usually 3 times, but today only 2 because I only ate one (big) meal. I sometimes get a wee tingle, but the vast majority of times nothing. Oh, and Happy Thanksgiving, y’all!

I’d never have the discipline to follow a schedule like that one you posted. If I can’t take something with my handful of supplements all at once after the midday meal, I find I’ll just forget to take it.

I’m a little over 2 months into it now, and in the past couple weeks have noticed a bit of a rash breaking out. I remember you said you got acne on your chest and back - well, I wouldn’t describe this as acne, which I think of as zits coming to a head and popping, which this doesn’t ever do, although it’s in the same locations. Just more of a bumpy rash. I suppose something is being flushed out of my system, and have no idea how long it will last.

I’ll always be able to remember I started doing this on Sept. 19, because it’s the same day the La Palma volcano began erupting. ;)