Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
I’m so ridiculously and hopelessly far behind in trying to follow Dmitry’s Telegram chat. But I saw him mention something in passing about Niatonin getting rid of fleas? Seriously? IDK how that would work, but my cats have to be on this if that’s true. We’re always facing infestations here in south FL, even tho we have no carpet and the cats stay indoors. And I have never wanted to subject them to any of those chemical drops that you put on their necks to turn their blood into flea poison. That can’t be good!
Oh, and if he changes the protocol again, someone please mention it here. Almost 3000 posts behind. Geesh, that chat has taken off like a runaway train lately!
25/1650, no flush. You need to hang out a shingle as the Niatonin Genius.
I’m thinking of putting the melatonin in a shaker to make it easier to portion out small amounts.
I did. She's driving from Wisconsin back to California, so that will eat up a few days, but I'm sure it will be at least a week beyond that. I just hope we don't see a niacin shortage.
That's a good idea. I have a skinny straw that I made a tiny spoon from.
I had tiny spoons already - that had never been used, but came in handy. But my scale has trouble registering tiny amounts of melatonin (thinking of the cats again).
AZL, is your shaker idea intended for both M and N together, or separately? I was wondering how well they would be homogenized if mixed, because they’re such different consistencies. It would be great if I could just mix up a batch of the Ratio blend, keep it in a small jar and then weigh out separate portions as needed. Ideally I’d need to get some really tiny jars to put each cat’s allotment in at one time, and then add them to the meals.
If the 66.7:1 figure is really magical, someone may yet come out of this with a useful product: a well-mixed version of Niatonin. It could be like iodized salt.
So much for “it can’t be bottled or sold because everyone is unique”, then.
Normies don’t want to buy scales and measure out white powders.
Someone(s) will make a killing on it. Then the FDA will want it banned.
Back to the drawing board. I tried the 66.7:1 solution at 1750N this morning, and my ears were burning before I had consumed 1/4 of the glass. I’m finishing the rest of it with pistachios.
My “success” yesterday must have been due to residual pistachios from earlier in the day.
This afternoon my husband wanted us to go somewhere, and I hadn’t eaten breakfast yet, so I made a fruit smoothie in a hurry. While making it, it occurred to me that we’d be out when I could be taking a dose of the protocol, so I just measured it out and dumped into the smoothie. Hardly any noticeable effect, maybe a slight drying of the facial skin (usual tingle precursor) was all. I was surprised. Still haven’t got any of the tart cherry concentrate, that’s on my to-do list.
Very cool about the smoothie. Now I can see an opportunity for a new chain of smoothie emporia. Haven’t thought of a good name yet. Smoothie Flush? Flush Smoothie? Um, no. Third Eye Smoothie, maybe.
That combination is something one could actually patent.
Morning 30M/1750N finally went fine, but only with pistachio assist (60P). I just did another 30M/1750N, with a few more pistachios and no flush.
I’m feeling a little drowsy, however, at 4:30 in the afternoon, so I’m wondering if the melatonin is responsible. Perhaps I’ll just go back to pistachios tomorrow.
Took 15M and 1000N at once tonight for the first time. Another milestone! Am having the weirdest inside-the-ears flush. Had that one time before. Wonder what it means? It feels so strange, like my ears have been pigging out on hot peppers! 🌶👂🏼 The earlobes are fine, though, just the insides are flushing. Every day is a new adventure! ;-)
Ya, keep munching.
Pistachios + 2KN today. Started out with a flush in the ears after I had barely started. A few more pistachios resolved the problem, but I’m wondering if the flush is a direct effect of having concentrated niacin in the mouth. For the next attempt I’ll try dissolving the niacin in 24 oz of water instead of 12 oz.
Straight from the horses' mouth on pistachios and #NIATONIN.
Work up to first doses while munching on pistachios for 4 days prior to first dose to alleviate severe flush - especially over 70's.
Then do the 66.7:1 ratio at 7M/500N mixed together 10 mins after cherry concentrate. pic.twitter.com/am9vg6dk29— WeThePeeple (@WeThePeeple9) October 17, 2021
Now he's saying 1-2oz tart cherry juice concentrate 7-10 mins before taking niacin and mellie together at 66.7:1 ratio. I'm, personally, drinking some cheery juice WITH my NIATONIN mix. It helps knock out some of the sour.
What brand/source for cherry concentrate?
My brother (with the eye problem) also had dry eyes, especially when he woke up in the morning. Since Niatonin, he no longer has dry eyes, and no longer needs to use eye drops in the morning. He theorizes that the improved circulation is doing a better job of feeding his tear ducts.
His wife, who also has dry eyes, is now thinking about starting Niatonin.
N2K again, this time in 24 oz of water. No flush at all.
The time I had the Niatonin mixed in my fruit smoothie, I couldn’t taste the sourness at all, and didn’t flush. I think I’ll put it in all my fruit smoothies from now on. I don’t really see any need now to get the tart cherry in a hurry, since the flushing seems to be greatly diminishing or ending altogether lately.
I think the cherry is mostly for long covid and severe vax injury. I’m using it to cut the taste of the 3KN I’m downing. The wife doesn’t make “that face” after drinking with the cherry too.
Good news. I was telling my ophthalmologist (who’s awake) about it. I’ll pass along this anecdotal tidbit.
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