Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
Sorry about that. A Barf Alert would have been entirely appropriate.
After getting rid of my candida and rehydrating, I’m now down 8 lbs (from 182 to 174) since this began. Today I went right back at it, recklessly restarting at 1500N. Sipping slowly I started flushing around 800N, and went back to the pistachios, throwing in some dried cherries as well. I completed the 1500, but with a nice pink tinge over my entire upper body. I hope it calms down before I see my acupuncturist.
No bliss today, my portal’s gone away.
Strange acupuncture today. Unlike every previous instance, I didn’t fall asleep. I just had a long, long meditation. Very pleasant, but the bliss never appeared. Perhaps I just need to catch up on my niacin. Or maybe my bliss came from my candida.
More experiments!
Costco has dried tart cherries for less than $10/lb. I guarantee there’s more cherry in that than in a quart of even concentrated juice.
Unfortunately there’s some controversy about whether melatonin is preserved during the drying process.
Hey, #1, I wonder if you’d have any tips for preparing something in advance for dosing my cats. I’m thinking 2 or 3 of them should be on this, and mealtime is too much of a scramble anyway with them eating all in different rooms, and with different diets in some cases...
I’m bad with figuring out mathematical formulas, but was thinking it would be a whole lot simpler if I could have something pre-mixed and put in dropper bottles so that I could just add each one’s “dose” to the meal without doing what I’m doing now- which is measuring the powders out before mealtime, and sticking them in spoons to add a dollop more of wet food to, to give them a while after they’ve had their meal. Any ideas would be appreciated! TIA
The amount for a cat would easily fit in a capsule. You could prepare a bunch of capsules in advance and them dump them out when needed.
You must have remarkably unfussy cats if they’ll eat food adulterated with niacin.
I had thought of that. Might be tricky telling them apart, but better than what I’m doing now.
The cats in question would eat anything, almost. They’re used to having supplements added. Feeding time is a grand competition, hence the need for separate rooms and areas for each of the 8. And it’s over in less than 3 minutes from the starting bell. ;-)
Gosh with cats the doses would be so small. I’m giving my 75 pound dog 25M and 800N. I made pills out of the melatonin. That’s the max N dose I’m going to give her (and she’s shown lots of improvement). For a cat at max 15 lbs you could try the 66.7:1 ratio. I’m thinking the 3mg store bought tablets might be the way to go with the small animals. So 3mg x 66.7 = 200mg. That sounds like a good dose for small animals.
As for the niacin dosing, you might want to look into the pre-mixed water scenario. In this instance you would make a 10% easy to calculate solution. Put 10g niacin in 990g water (total 1000g = 1L). You’ll need some kitchen scales that handle a larger load than the mg scales we’ve all been using for mellie and niacin doses. When you want to dose, you weigh the niacin solution. 20g of solution = 200mg niacin. With this method it’s also easy to measure your dosing by volume. 20g = 20ml. You probably have measuring cups that have metric units.
20g of solution = 200mg niacin. With this method it’s also easy to measure your dosing by volume. 20g = 20ml.
I have a kitchen scale, but was hoping to avoid weighing altogether once a solution is made. I have these 20ml amber dropper bottles, and thought I might fill them up with a pre-ratioed mixture (not buying small M tablets as I’d have to crush them anyway, best to just use powder). The question remaining is how many doses can I fit in that bottle? Conventional wisdom says something like a dropperful equals 1ml, but I guess that depends on how full you fill it. I’ve never paid that strict attention, but this probably isn’t an exact science, either.
Say 30 doses in the 20ml bottle? Feasible? (Markings on my measuring cup only go down to 50ml, so I’ll use the bottle to measure. I’ve never even looked at that side of the cup before!) So, niacin 200mg x30 =6g. And for the melly, 3mg x30 = 90mg. All that seems like an awful lot to dissolve in that little amount of water, but who knows. If it doesn’t fully dissolve, then will have to shake well before using. 2 dropperfuls for each dose. Won’t know until I try, I guess.
I just want something I can simply squirt into the cats’ wet food before giving it to them, without thinking too much at the time, as it’s crazy enough already preparing their meals (I have to hide the dishes in the microwave and use its door as a shield); while fending them off as they lurk about, jumping on the counter, fighting one another, salivating, trying to get in a “sneak pre-bite”.
Off to experiment with measuring and mixing potions, like the mad scientist I never was...
Nope, that’s not gonna work. Back to the drawing board....
First time at 1600N today after 60P and a few dried cherries. Warmth around the ears. I’m back on track.
I’m starting to spread the word in another of my communities. I think I have a new convert. She placed her Pure Bulk order today.
66.7:1 Go there.
I did 45M/3000N NO FLUSH after lunch. This morning I did 30M/2000N. The ratio is magical.
Proselytizing!
And so it will be. Thank you, #1Guru.
Are you now off pistachios?
Back to maffs, I find it easier to think of your 66.7:1 rule as a 1.5% rule. Take your N and multiply it by 1.5% to get your M.
I’ve been taking 10M and 670N twice a day for a couple days now. Tingle is minimal and of short duration, and I just keep on doing whatever I’m doing and ignore it. I detect no noticeable difference between eating pistachios or taking NAC beforehand, or not.
I’ll leave the hardcore competition to you guys.
Yes, and seeing what happens. I'm sick of them anyway. I'm so niacin saturated now. But I did 45/3000 today and not a tingle. Maybe even a little groggy. Gave the wife her first dose sans pistachios 20 mins ago at 23/1500. We'll see what happens.
My aim is to fix what we've done to ourselves smoking. It's not too bad because we haven't smoked poison cigs for maybe 20 years. We smoke organic tobacco. We're also very good eaters. Never really much processed food our entire lives. I've always been into some hippy dippy health stuff since I was a teen. We've done a LOT of experiments.
Nothing is wrong with us, but we were seeing signs of breathing issues coming fast. The change in breathing since being on the protocol has been wonderful. It's like I didn't know how bad it was.
Pro tip: if you stay at the ratio, any flush at higher doses will not be more intense. Counterintuitive, but true.
I believe you. But why would I want higher doses? I live a very clean and healthy lifestyle too. This is a higher amount already than I ever imagined taking at the outset. I think I’m good here. You don’t?
I think I have a new convert. She placed her Pure Bulk order today.
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