Is Ivermectin effective against Covid? A Dispassionate Look at Four Reasonably Large Randomized Controlled Trials

Sebastian Rushworth M.D. ^ | 01/17/2021

[SeekAndFind]

Ping for your interest

[sauropod]

Bkmk

[SeekAndFind]

This was an article written January this year, reviewing the research done in 2020.

A follow up article was written 5 months later, which can be seen here.

This was a the author's conclusion upon further study:

What we see is a 62% reduction in the relative risk of dying among covid patients treated with ivermectin. That would mean that ivermectin prevents roughly three out of five covid deaths. The reduction is statistically significant (p-value 0,004). In other words, the weight of evidence supporting ivermectin continues to pile up.

It is now far stronger than the evidence that led to widespred use of remdesivir earlier in the pandemic, and the effect is much larger and more important (remdesivir was only ever shown to marginally decrease length of hospital stay, it was never shown to have any effect on risk of dying).

[billyboy15]

After reading this I have come to the conclusion that taking Ivermectin has a great chance of helping one get through the china virus along with a likely zero chance of doing harm based on how long it has been around.

[ProtectOurFreedom]

"I’m not sure why these studies keep focusing on people with mild disease, since it’s more important to find an effective treatment for severe disease. I guess it stems mainly from a hypothesis that ivermectin is unlikely to be effective if given later in the disease course."

Many studies have shown Ivermectin has best efficacy as a pre-exposure and post-exposure prophylactic and in the early stages of the disease. It's surprising to me that the author says he "isn't sure why these studies keep focusing on people with mild disease." Studies of both HCQ and IVM going back to Q1 2020 showed that the medications are nowhere near as effective in the late stages of the disease as they are in the early stages.

---

"However, all four trials had major flaws, and two of the trials that did find a benefit were also giving doxycycline, which makes it impossible to disentangle whether the potential benefit was coming from ivermectin or doxycycline."

Dr. Paul Marik, in his "COVID-19 MANAGEMENT PROTOCOL: An overview of the MATH+ and I-MASK+ Protocols writes:

"While there is no cure or “Magic-bullet” for COVID-19, recently, a number of therapeutic agents have shown great promise for both the prevention and treatment of this disease including Ivermectin, Vitamin D, quercetin, melatonin, Vitamin C and corticosteroids. It is likely that no single drug will be effective in treating this complex disease and that multiple drugs with different mechanisms of action used in specific phases of the disease will be required. Furthermore, a growing body of evidence suggests that many of these agents may act synergistically in various phases of the disease." (page 6)

"...We developed the MATH+ protocol to provide guidance for the treatment of the late pulmonary phase of this disease with the goal of reducing the hospital mortality from COVID-19. However, it has now become blatantly clear that our emphasis needs to shift to the prevention and early treatment of this catastrophic disease to prevent patients progressing to the pulmonary phase and requiring hospitalization. Hence, we developed the I-MASK+ protocol.

I swear authors such as Dr. Rushworth here are not well read nor well-informed on the disease. Their naiveté is often revealed in their writing.

[billyboy15]

“That would mean that ivermectin prevents roughly three out of five covid deaths.”

So then if the use of Ivermectin and most likely Hydroxachloroquine had been permitted there would have been approximately 370,000 fewer deaths from the China Virus in the US.

Someone needs to hang for this....seriously.

[gas_dr]

Thank you for posting this -- there was a long discussion on another thread. One of the studies used it the meta-analysis published by FLCCC, at ivmmeta.com

Vaccines and treatments are both extremely valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases the risk of COVID - 19 becoming endemic; and increases mortality, morbidity, and collateral damage. We do not provide medical advice So, the very literature some use to bludgeon others on this thread clearly points out that vaccines and treatments are complementary.

The reason that I post this is that there are those who believe that ivermectin is a cure -- it is not in my judgment and from treating several patients with it and seeing them progress (and yes some were even quite early)

I have arrived at the conclusion that every source that talks about the pandemic demonstrates what we have known all along -- that vaccines and treatments are complementary and should be used in tandem. The one treatment that I have seen work even in patients getting awfully close to late phase is Regeneron which also shows good activity against delta variant. Delta variant, for what it is worth, appears a lot more transmissible but somewhat less dangerous. I can say clearly in our area, hospitalizations are way up, but not as many in the ICU. The majority of patients I am seeing are not vaccinated. This is across several large hospitals in a major metropolitan area.

[grey_whiskers]

Thank you for being honest enough to reference/quote the follow up article.

I consider you honest anyway, but a lot of pro-jab trolls on the site aren’t.

[FamiliarFace]

Thank you for the insight. What do you think of early treatment with ivermectin? Surely it couldn’t hurt if someone caught this virus, could it?

[a real Sheila]

“There are currently five trials of ivermectin for covid listed as completed at clinicaltrials.gov, but for which results haven’t yet been published. However, four out of those five were completed less than two months ago, and one was completed three months ago, so most likely they just haven’t gotten around to posting their results yet.”

Gee, I wonder what$ taking $o long!

I’m sure all of those reports were on ONE single thumb drive, which has probably been lost.

[Rad_J]

I have been sick with Covid for one week and have lost 17 lbs
Yesterday I could barely get out of bed.
I took Ivermectin yesterday and today I was able to get up and make myself breakfast and take a shower. Two relatives who live nearby also took ivermectin yesterday and both were able to get out of bed some today. All 3 of us are under 50.

[airborne]

I went to TSC (Tractor Supply Center);today and saw a package of Ivermectin on the shelf.

I wish I had looked closer but I was in a hurry.

[gas_dr]

Well it could. Ivermectin is a macrolide antibiotic (produced from spreptomyces, macrolide endectocide to be very specific). It is likely this that gives anti-inflammatory effects. I worry about using an antibiotic as it may breed downstream resistance. For example, a lot of CoVID PNA sets up to a secondary infection. One of the late treatments that is authorized is tocilizumab. This is a heavy hitting immunosuppressant — the reason I worry about early abs use is that if a patient develops horrendous PNA after immunospression to quell shock, then you are kind of screwed in terms of treating the superinfection.

There are always risks to any medication. I think it could hurt by delaying better and more appropriate care.

Were I to get sick with CoVID I would without delay do the following:
—Start decardon 6 mg a day for 5 - 10 days
—Immediately procure Regeneron infusion (Casirivimab + Imdevimab)

As of right now these are the options that promote the greatest safety to prevent progress to severe disease.

[LostInBayport]

May I ask how you determined your dosage? I’m assuming you used the paste.

Wishing you well too.

[Oscar in Batangas]

You should have bought it without hesitation, diluted it to human proportions and sold the portions on E-Bay

I haven’t hear of a SINGLE tractor dying from COVID (SARC)

There’s another company in Marysville, KS,- ValleyVets, I believe, that showed appropriate dosages per kg of animal weight.

Run the ratios and divide by two (animals have 4 legs, humans have two) and you may have a good treatment. More SARC??? Probably just as accurate as anything Fake-Views Falsey puts out therr

[Rad_J]

This was in pill form. I was told to take 4 small pills then wait 2 days and take 4 more.

[SeekAndFind]

RE: have been sick with Covid for one week and have lost 17 lbs
Yesterday I could barely get out of bed. I took Ivermectin yesterday and today I was able to get up and make myself breakfast and take a shower.

Skeptics will say that the disease had taken its natural course and you would have recovered with or without Ivermectin since over 99.7% of people do.

[Rad_J]

True. But after days of suffering, any relief is welcomed. I am also glad I didn’t have to go to the hospital.

[Man from Oz]

The wife and I just coasted through the Gamma variant. We followed the flccc.net protocol and added a z pack antibiotic on top of the Ivermectin, vit D and Zinc.

We ARE NOT vaccinated and will never touch the shit. Between a cousin with a stroke and a brother w Shingles from taking either Moderna or Pfizer, , we deem the risk to high to trust govt assholes.

Symptoms were low grade fever, tired, no appetite. I had my lungs checked last fri and all was clear.

I just ordered another 78 Ivmectin tabs through pushhealth.com. The cost of this service is @$63 dollars per script and off insurance. The cost per .3 mg tab is @ $1.45 per.

Be proactive and don’t let your primary care or pharmacist spout the state BS line. You need to take personal responsibility for your own health.

With all this said, I hope big pharma and govt hang by a noose when the shit sees the light of day.

MFO