[Steve Van Doorn]

Have you had any effects eating pistachios? They have the highest concentration of melatonin of any food.

Melatonin makes cortisol hormone. It also reactions with a lot of drugs. If you don't take in enough Melatonin... you're cells are not feeding enough and not sleeping right.
https://www.drugs.com/drug-interactions/melatonin.html

[little jeremiah]

I never have problems with pistachios, eat them very rarely. DH brought home some from Costco so I had more pistachios in a few weeks than I’ve had in 25 years (almost never) and I noticed nothing. I would eat maybe 10 at a time at most.

My body chemistry (or whatever) seems a bit unusual as it reacts badly to so many things that most people have no problem with.