Once I saw a black bear in Canada that was as big as the front of an old school four wheel drive Bronco that I was in. He crossed the road in front of us. There are legendary creatures out there, those are the ones you run into when you’re outgunned.
About 350 is about as big as I see them here, no need to lug an N frame around. 10mm cast has the oomph to penetrate head to tail. I switch to 180gn hp when I’m only worried about mountain lions.