My state-side VP boss tried to buck up my hesitance in making executive decisions. He said to think like a quarterback, where anything over fifty percent pass completion was good. I thought of it as making irrevocable decisions based on insufficient information. I later learned that this is the art of business.
There are however many(most) science fields that still have unknowns. My back fence neighbor is a “gold” geologist. He is very good and highly sought out for investigations of mining site potential yield. He will admit after few drinks that geology is not an exact science. Sure he can lab test specimens but when it comes to some big issues like “how did this form - exactly” that there are some assumptions.
Meteorology suffers from over mediazation. I quit watching TV for weather forecasts, I go straight to my Indian Weather Rock or the weather service.