I've shot the .454 Casull version of that gun with full-house loads. It's not as bad as you might think. You won't be shooting more than 25 rounds of that stuff, though.
With mild .45 Colt loads it shoots like a .38 Special, and you can do that all day long.
I have to deal with black bears only in my area and I carry a 6 1/2 inch .44 magnum Virginian Dragoon with hunting loads when I am working around the house. If I confront a bear in my yard that won’t move on they get #8 shot from my Mossy 500 in the rump as an inducement. I keep a couple rounds of #8 up front in the .12 gauge and then three slugs in case the bear charges. The #8 in the tail usually sends them scurrying off quickly.