There are two presidents concerning who the evidence is rather strong that they had STDs:
Abraham Lincoln and John F. Kennedy
Lincoln appears to have contracted his as young man, and I’m not aware that it or philandering played any role later in his life. JFK was a serious adulterer, like Lyndon Johnson and Bill Clinton. He was wracked with all kinds of illnesses, and was heavily medicated all the time. The following is from a review of his medical records from 1955 to 1963. I suspect even this one examination was filtered by the keepers of his records:
At work on a Kennedy biography, Dallek became the first scholar to examine J.F.K.’s medical records on file at the Kennedy presidential library in Boston. Somewhat to Dallek’s surprise, a summation of his discoveries published in the December issue of the Atlantic Monthly has set off a firestorm. It’s not news that J.F.K. was in poor health much of the time, but Dallek paints the fullest and most unnerving picture yet of a President in constant pain from degenerative bone disease and heavily medicated.
“When I read about the hospitalizations, my eyes widened,” says Dallek. “We never knew about this.” Another revelation was the sheer quantity of medications Kennedy took daily during his presidency. “Steroids for his Addison’s disease,” Dallek writes, “pain-killers for his back, antispasmodics for his colitis, antibiotics for urinary-tract infections, antihistamines for allergies and, on at least one occasion, an antipsychotic (though only for two days) for a severe mood change that Jackie Kennedy believed had been brought on by the antihistamines.”
Evidence?