Our military professionals clear houses with their 5.56 rifles. Sidearms are only drawn as a last resort.
With many choices to go to, my home defense bedroom firearm is a 20 gauge double Ithica...two triggers...with 3 buck.
Back up is a 40 cal glock 23 with 135gr hps in two mags. Have bandoleer of back up 3 buck too.
Chose the 20 over the 12 in case my wife needs it. Also, don’t plan on shooting individuals across the street. I want to defend the inside of my home, not the neighborhood. For that I have better.
If that does not clear the threat, well, send me back to firearms training.