“Ibuprofen is extremely hard on the kidneys as well.”
Especially risky to maybe 5% of the population. Ibuprofen is linked to nephrotic syndrome. It least can trigger it, maybe in some cases cause it or another chronic kidney disease. All NSAIDs should be avoided by those who are at risk of kidney disease.
I don’t have nephrotic syndrome but I do have CKD (stage 3) so have to be careful with a number of things.