Why, YES, that can be done! See, for instance the efforts on the 45 Super, the .45 Atomic or the beginnings of the .45 Winchester Magnum in the NAACO Brigadeer, circa 1959. Oh, that'd be a 230-grain bullet at 1600 FPS/500 MPS....
It was a Wildey pistol in .45 Win Mag. Quite the handful.
Merry Christmas!
L