All powers not enumerated in the constitution to the federal government are reserved for the states or the people.
hence the people are sovereign.
The precise language of the Tenth Amendment is “The powers not delegated to the United States by the Constitution nor prohibited by it to the States, are reserved to the States respectively, or to the people.”
There is no provision in the Constitution that directly binds individuals, except for 13th Amendment against individuals owning slaves. Other than the prohibition on owning slaves, the feds have NO Constitutional power over individuals. The Constitution is an issue between the states who ratified it and the federal government which the Constitution created and under which the feds are bound.
Meanwhile, the people exercise their political power upon their own state. That is our decentralized republican form of government.
It is the people THROUGH THEIR INDIVIDUAL STATES who now need to stand up against and nullify the unconstitutional acts of the feds which by definition are acts of tyranny.