How can that possibly be without some time of feedback system? I see no evidence of any feedback loop in the TPM/matrix delivery product. Instead of taking 10 days to get to the maximum therepeutic dose it would take 1/3 - 1/4 as long.
I credit you with at least doing some research. However despite that you have reached an incorrect conclusion, partly based on looking at some very old clinical trial results. It no longer takes 10 days to reach a therapeutic dose - now it is about 24 hours due to improvements in the patch configuration between early experiments and the development of the final commercial configuration.
As for your feedback comment, you are right, and the feedback is essentially the same as it is in any equilibrium situation. Once the therapeutic dose is achieved, the patch releases only enough active to replace the drug as it is metabolized.
The rate the drug migrates through the skin is dependent on the gradient. As plasma concentration rises, the rate of migration through the skin drops.
Maybe you’ll just have to take my word for it at least for now.