My Great Grandparents also settled in the lower east side. Cherry Street, E10th Street and E15. They came from Melitillo Catania Sicily and Palermo.
My Irish relatives lived on East Houston and points south ... Cannon Street, Sheriff St, East 2nd Street to name a few.
The German side lived on Avenues B and C, just north of Houston.
North of E Houston was known as Klein Deutschland (little Germany) until the early 1900s.
The LES was primarily German in the early 1800s, then the Irish, Italians, Jews and Chinese came in their respective waves.
If you get to NYC I strongly recommend the Lower East Side
Tenement Museum.