The only thing it would accomplish would be to start Civil War Revolutionary War II.
This would not be a "South" vs. "North", but rather a "we the peoples" vs. the "Government".
...That whenever any Form of Government becomes destructive of these ends, it is the Right of the People to alter or to abolish it, and to institute new Government, laying its foundation on such principles and organizing its powers in such form, as to them shall seem most likely to effect their Safety and Happiness.
Not necessarily. If they pass the Deathcare crap, and certain states secede (opt out) there very well could be another Civil War.