“She revealed herself to be a rather ill educated laymen when she said that most mutations are deleterious and most of the rest are neutral. Over 90% of mutations in humans are neutral to selective pressure”
You see, another logical error. It is the possibility that such a thing as “selective pressure” exists in speciation. that is the topic of Ms Hewitts comments. But here you are, trying to use the topic under discussion as a fact of absolute incontrovertability and a proof of your position.
You cant use one problem to argue another.
Please quote me the paper I can read that demonstrates unequivicably that mutation and “selective pressure” led to a clear speciation change. And I’m not talking same species but cant reproduce garbage.
Please quote me the research that demonstrates which gene(s) control morphology, and how they do it, and how they change it.
When you say most mutations are neutral or benign, or you talking coding sequences, or repeat, and highly repeat non-coding sequences?
Can you explain why the highly deleterious mutation expressed as thalaessemia and sickle cell both persist in populations even without the unproven but claimed selection pressure of being unfavourable to mosquito infestation?
Can you challenge me that proteins and enzymes are dependent on their environment for the tertiary folding and therefor their activity? Name an enzyme that is effective if the cellular pH drops much below 7.4 - lets say even to 7.0, or goes above 7.9.
What causes protein denaturation? What exactly is that denaturation if not a change in tertiary structure first.
What was the major problem for the early pioneers in making human insulin from cloned genes? (It was difficulty with the disulphide bridge needed to finalise tertiary structure).
Your comment about watching DNA form its helix is priceless. Thanks, you confirm what I said. But you dont mention the constituents it’s in. And that still doesnt change the fact that chromosomes - which are the active form of DNA - are’nt just DNA, but associated with protein - chromatin - and need an exact environment. Nor that unravelling is a very specific operation needing very specific enzymes - topoisomerases - and that all this supports the contention that active cellular components only operate under very tight, specified conditions.
Why dont you discuss science, mr allmendream, who does theory work in a Pharmaceutical company.?
Try and be a little different young man. Try not to be offensive and obnoxious just because someone has trodden on your toes.
Ms. Hewitts piece, incidentally, was put here with neither her knowledge nor consent. It was a private posting in an e-zine, and the descriptions of her there were not hers but the site owners. The piece was a response to a number of comments on a forum thread, not a thesis, nor even an assignment. It also contains a couple of sophistacated jokes which you’ve missed.
Her views are the sum of more than 20 years reading, studying and thinking and discussing in the area of molecular evolution, after doing molecular research of her own.
And she is not alone in her views that Darwinism and selective pressure as an explanation for speciation are wrong.
Perhaps you’d better do a little reading around yourself.
Oh, and try a recent Nature publication regarding an experimentally based theory on how deleterious mutations might be protected in D. melanogaster.
See, they do exist as well.
If two populations cannot interbreed they are, by definition, two different species. So your “not talking same species but can't reproduce garbage” is exactly that, nonsensical garbage.
Hox genes. Look them up on Pubmed.
Mutations can take place anywhere in the genome, and I did not say that most mutations are neutral or benign; I said they are by far mostly neutral and most of the rest are detrimental. Pleas try to keep up.
Sickle cell anemia heterozygous is not about mosquito infestation except tangentially; it has a demonstrated effect of protection against malaria - which is carried by mosquitoes.
The proteases in the stomach operate at a pH of around 2. Also many digestive enzymes within the cell only operate in localized low pH vesicles called lysozomes.
You are confusing me with another poster about DNA annealing. Once again (as with your ranting post #62)you are very confused, please try to keep up.
Sophisticated jokes? Oh if it is all a joke then GOOD ONE! You got me. I figured the only way someone could pack that many errors in so few words was if it was a joke.