Yes. And, as I've mentioned, there were almost no Catholics or Jews in the earliest waves of English colonization. (Puritans in Massachussetts, Quakers in Pennsylvania, Protestants of various stripes in Maryland and Virginia, etc.) Later, especially 19th century, waves of immigration changed the mix.
I'm not going to mention how the whole line of argument about a lack of Catholic and other signers of the D of E strikes me, as I've mentioned it elsewhere. ;)