Isn't that a bit turned around? The Tenth Amendment states:
"The powers not delegated to the United States by the Constitution, nor prohibited by it to the States, are reserved to the States respectively, or to the people."
Since the Constitution doesn't delegate to the United States the power to regulate drug use, agriculture or State laws, so long as those laws aren't specifically prohibited to the States by the Constitution, (and in this case they are not) then it would seem that the supremacy of Constitutional law favors the State here.