[Rockingham]

Quite possible. Even under medical supervision, opiates have a thin margin for error that all too easily leads to accidental overdoses.

[eyeamok]

I never had that problem when I was addicted to opiates, 50 Percodan a day, but I was taking them for real pain, not to get high...

[catnipman]

“Even under medical supervision, opiates have a thin margin for error that all too easily leads to accidental overdoses.”

i’ve taken opiates for pain after major surgery and not once has a doctor told me there was “a thin margin for error” ... never have read that anywhere either ...

now there ARE tons of drugs that DO have well known thin margins of safety, such as most of the cardiac anti-arrhythmics, digoxin, et. al. ...

here’s a full list:

https://go.drugbank.com/categories/DBCAT003972