Free Republic
Browse · Search
Smoky Backroom
Topics · Post Article

To: narby; xzins; furball4paws
More on the Nylon Bug here.
1,679 posted on 12/20/2005 9:43:45 PM PST by MRMEAN (Better living through nuclear explosives)
[ Post Reply | Private Reply | To 1469 | View Replies ]


To: MRMEAN; narby; xzins; Right Wing Professor
I have read the paper. It is indeed a step forward, but not a giant step. Let me explain.

Nylon is:

[-CO-R-CO-NH-R'-NH-]n

The researchers used nylon hexamer (n=6) as a substrate, but real nylon has n>6. So this bug, while it can eat nylon waste and small pieces from manufacture cannot handle the large polymer. It also has a very high Km = 6x10-3M meaning that it has very poor affinity for the nylon hexamer. However, selective mutation should be able to reduce the Km and they also should be able to gradually increase the size of the oligomer substrate. This is the kind of thing that nature would do under natural conditions. The tough part of nylon isn't that an organism cannot hydrolyze the amide bond - that's a piece of cake, but the enzyme cannot get to the amide bond in a water insoluble polymer.

MRM - I think your original point is well taken and this is a nice example of evolution and some of the processes that can be involved. But this bug doesn't really degrade nylon, yet.

RWP - what's the usual "n" for nylon (my Merck Index doesn't say exactly)?

1,859 posted on 12/21/2005 10:48:28 AM PST by furball4paws (The new elixir of life - dehydrated toad urine.)
[ Post Reply | Private Reply | To 1679 | View Replies ]

Free Republic
Browse · Search
Smoky Backroom
Topics · Post Article


FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson