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Abstract Viruses such as human cytomegalovirus (HCMV), human papillomavirus (HPV), Epstein–Barr virus (EBV), human immunodeficiency virus (HIV), and coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2]) represent a great burden to human health worldwide. FDA‐approved anti‐parasite drug ivermectin is also an antibacterial, antiviral, and anticancer agent, which offers more potentiality to improve global public health, and it can effectively inhibit the replication of SARS‐CoV‐2 in vitro. This study sought to identify ivermectin‐related virus infection pathway alterations in human ovarian cancer cells. Stable isotope labeling by amino acids in cell culture (SILAC) quantitative proteomics was used to analyze human ovarian cancer...

Researchers have successfully identified over 5,000 proteins that are present in embryonic stem cells, tripling the size of previous results and in the process creating the largest quantified protein map to date. Stem cells hold great potential in biology and medicine, but a host of questions lingers about how they operate and convert into other cells. To help answer these questions, researchers have begun taking a 'big picture' approach, identifying all the proteins that are expressed in stem cells. Currently, around 1700 proteins have been identified in stem cells. Now, using mass spectrometry and special "heavy" amino acids (made with...

One day soon patients may spit in a cup, instead of bracing for a needle prick, when being tested for cancer, heart disease or diabetes. A major step in that direction is the cataloguing of the “complete” salivary proteome, a set of proteins in human ductal saliva, identified by a consortium of three research teams, according to an article published today in the Journal of Proteome Research. Replacing blood draws with saliva tests promises to make disease diagnosis, as well as the tracking of treatment efficacy, less invasive and costly. Saliva proteomics and diagnostics is part of a nationwide effort...

Jill Doimer's mother died in 2002 from ovarian cancer, detected too late to be effectively treated. So Ms. Doimer is eagerly awaiting the introduction of a new test that holds the promise of detecting early-stage ovarian cancer far more accurately than any test available now, using only blood from a finger prick. Not only does she plan to be tested, but an advocacy group she helped found, Ovarian Awareness of Kentucky, also intends to spread the word to women and doctors. "If it's going to happen to me or anyone I know, I want it to be caught at an...