Keyword: multiplesclerosis

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  • Human Patients Treated for MS With Adult Stem Cells

    06/29/2008 6:33:31 PM PDT · by Coleus · 4 replies · 254+ views
    psl group ^ | 06.11.08 | Judith Moser, MD
    NICE, France: In patients with multiple sclerosis (MS), immunosuppressive therapy followed by autologous haematopoietic stem cell transplantation elicited high response rates and improved quality of life for up to 6 years. The results of the study were presented here at the 18th Meeting of the European Neurological Society (ENS) by Tatiana Ionova, MD, PhD, Department of Haematology, Pirogov National Medical Surgical Center, Moscow, Russia. During the last decade, high-dose immunosuppressive therapy followed by autologous haematopoietic stem cell transplantation has been used with increasing frequency as a therapeutic option for patients with MS. "The aim of the study was to assess...
  • Fluoxetine (Prozac) May Help to Curb Disease Activity in Multiple Sclerosis

    05/11/2008 5:55:46 PM PDT · by balls · 12 replies · 583+ views
    British Medical Journal via DGNews ^ | May 6, 2008 | British Medical Journal
    LONDON -- May 6, 2008 -- The selective serotonin reuptake inhibitor (SSRI) fluoxetine (Prozac) may help to curb disease activity in patients with the relapsing-remitting form of multiple sclerosis (MS). That's the finding of preliminary research published ahead of print in the journal of Neurology Neurosurgery and Psychiatry. The research team randomly allocated 40 patients with the relapsing-remitting form of MS to treatment with either 20 mg daily of fluoxetine (Prozac) or placebo for 24 weeks. All patients underwent magnetic resonance imaging every 4 weeks to check for new areas of neurological inflammation, a hallmark of active disease. In total,...
  • Genentech and Biogen Idec Announce Top-Line Results from a...Clinical Trial of Rituxan in...MS

    04/16/2008 10:21:37 PM PDT · by neverdem · 243+ views
    centredaily.com ^ | Apr. 14, 2008 | NA
    Genentech and Biogen Idec Announce Top-Line Results from a Phase II/III Clinical Trial of Rituxan in Primary-Progressive Multiple Sclerosis SOUTH SAN FRANCISCO, Calif. & CAMBRIDGE, Mass. — Genentech, Inc. (NYSE:DNA) and Biogen Idec, Inc. (Nasdaq:BIIB) today announced that a Phase II/III study of Rituxan(R) (rituximab) for primary-progressive multiple sclerosis (PPMS) did not meet its primary endpoint as measured by the time to confirmed disease progression during the 96-week treatment period. Genentech and Biogen Idec will continue to analyze the study results and will submit the data for presentation at an upcoming medical meeting. "We are disappointed in the outcome of...
  • From Multiple Sclerosis, a Multiplicity of Challenges

    03/06/2008 9:55:53 PM PST · by neverdem · 21 replies · 372+ views
    NY Times ^ | March 4, 2008 | JANE E. BRODY
    When it comes to understanding, preventing and treating chronic diseases, multiple sclerosis ranks among the most challenging. The word “multiple” is apt in more ways than one. Various suggested causes include early-life exposure to certain viruses or toxic agents, geographic and dietary influences, inherent immunological defects and underlying genetic susceptibilities. MS is highly unpredictable. Rarely are any two patients alike in the presentation, duration and progression of symptoms; even the underlying cause of disability in MS is being reconsidered. And rarely do any two patients respond in the same way to a given therapy, be it medically established or alternative....
  • BREAKING: Study Shows Genentech and Biogen Drug Rituxan Works on Multiple Sclerosis

    02/13/2008 5:56:16 PM PST · by balls · 85 replies · 575+ views
    CNBC ^ | Wed Feb 13, 2008 5:19pm EST | Mike Huckman
    CNBC’s Mike Huckman reported on a study just released in the New England Journal of Medicine that found that Rituxan, a joint-venture between Genentech and Biodec intended for use on rheumatoid arthritis and non-Hodgkin’s lymphoma, is also useful in treating M.S. According to the study, patients using Rituxan saw a 58% decrease in M.S. flare-ups and a 91% drop in brain legions after just two infusions of the drug. This news has huge upside potential for Genetech, Huckman said. It could be a mixed bag for Biogen because the company makes two other multiple sclerosis drugs whose sales could be...
  • Scientists Find Way to Track Stem Cells in Brain

    11/27/2007 8:17:27 PM PST · by Coleus · 40+ views
    HealthDay News ^ | Nov. 8, 2007 | E.J. Mundell
    The identification of a new marker is making it possible to track brain stem cells for the first time, U.S. researchers report. The achievement is already opening doors to new research into depression, early childhood development and multiple sclerosis, the team's senior author said. "This is a way to detect these cells in the brain, so that you can track them in certain conditions where we suspect that these cells play a certain role," explained Dr. Mirjana Maletic-Savatic, an assistant professor of neurology at the State University of New York, Stony Brook. "This is also very applicable for situations where...
  • The Good News Just Keeps On Coming: Adult Stem Cells Treat MS and Arthritis in Mice

    11/26/2007 8:14:24 PM PST · by Coleus · 54+ views
    Wesley J. Smith ^ | November 22, 2007 | Wesley J. Smith
    As we celebrate the creation and potential of induced Pluripotent Stem Cells, adult stem cell research continues to bear fruit in animal and human studies. The latest is a truly exciting find out of Stanford University: Blood stem cells taken from a donor with a healthy immune system effectively treated multiple sclerosis and arthritis in mice. From the story in the Telegraph: Thousands of patients with arthritis and multiple sclerosis are given new hope today by scientists who have developed a way to alter the immune system.Both conditions are caused when the immune system becomes faulty and attacks the body....
  • Hadassah uses stem cells for MS, ALS patients

    11/26/2007 8:08:17 PM PST · by Coleus · 3 replies · 213+ views
    The Jerusalem Post. ^ | Nov 22, 2007 | JUDY SIEGEL-ITZKOVICH
    Neurologists at Jerusalem's Hadassah-University Hospital, Ein Kerem, are the first in the world to help multiple sclerosis (MS) and amyotropic lateral sclerosis (ALS) patients by injecting their spinal columns with large numbers of adult stem cells taken from their bone marrow and multiplied in culture. The clinical trial, while "encouraging" and "promising," remains highly experimental, as all the patients have undergone a single injection with no untreated control group for comparison. With the first patients having received it two years ago, it is too early to know how successful it will be in the long term. Prof. Dimitrios Karousis, a...
  • Hope for safer bone marrow transplants

    11/26/2007 7:54:23 PM PST · by Coleus · 38+ views
    Guardian News ^ | November 23 2007 | Ian Sample
    Patients with common immune disorders such as multiple sclerosis and rheumatoid arthritis could one day be treated with bone marrow transplants, scientists claimed yesterday. Hopes for the new treatment follow the development of a more efficient transplant technique which avoids the need for radio- or chemotherapy, both of which have potentially dangerous side-effects. Traditional bone marrow transplants are used to treat only life-threatening conditions, such as leukaemia or lymphoma. The treatment infuses healthy adult stem cells into the patient, which then form fresh blood and immune cells. But before the transplant can be done, patients must receive a course of...
  • A new treatment for multiple sclerosis (MS) is being pioneered with Adult Stem Cells

    09/29/2007 8:35:25 PM PDT · by Coleus · 6 replies · 212+ views
    bbc ^ | September 26 , 2007
    A new treatment for multiple sclerosis (MS) is being pioneered near Bristol. Six patients at Frenchay Hospital are being injected with their own stem cells in the hope that they will repair damage to the brain. Approximately 60,000 people in the UK suffer from MS, an incurable disease of the nervous system. Prof Neil Scolding, of the Institute of Clinical Neurosciences, said: "We know stem cells are attracted into the brain, into these areas of damage." He added that he hoped the stem cells would "help those areas to stop getting worse" and "repair damage". 'Lot of hope' Liz Allison,...
  • Scientists Help Multiple Sclerosis Patients Without Embryonic Stem Cells

    08/14/2007 4:05:10 PM PDT · by wagglebee · 18 replies · 394+ views
    Life News ^ | 8/14/07 | Steven Ertelt
    London, England (LifeNews.com) -- Scientists in England have developed a vaccine that, in early testing, appears to help patients with multiple sclerosis without relying on controversial embryonic stem cells. Pro-life advocates oppose the use of the cells because days-old unborn children must be destroyed to get them. Dr. Amit Bar-Or and researchers at the Montreal Neurological Institute developed a vaccine that relies on the insertion of healthy DNA into a patient with the debilitating disease. Bar-Or tested the BHT-3009 on 30 patients where half received the injection and half received a placebo. The London Telegraph reports that the numbers of...
  • Advances Cited in Research on Multiple Sclerosis

    07/29/2007 4:44:55 PM PDT · by neverdem · 17 replies · 688+ views
    NY Times ^ | July 29, 2007 | NICHOLAS WADE
    Medical researchers have made a significant advance in understanding multiple sclerosis, a common neurological disease that causes symptoms ranging from muscle weakness to paralysis. The disease is one in which the body’s immune system mistakenly attacks the electrical insulation of nerve fibers. The cause is part genetic and part environmental, but researchers trying to identify the relevant genes have endured repeated frustration. Their approach has been to guess what genes might be involved and see if patients have abnormal versions. This guesswork has produced more than 100 candidate genes in recent years, none of which could be confirmed except for...
  • Obituary Notice Leaves Evidence That Canadian Woman Was Killed at Zurich's Assisted Suicide Clinic

    06/21/2007 4:21:28 PM PDT · by wagglebee · 1 replies · 260+ views
    LifeSiteNews ^ | 6/21/07 | John-Henry Westen
    HALIFAX, June 21, 2007 (LifeSiteNews.com) - Elizabeth Jeanette MacDonald of Windsor Nova Scotia recently died at the Dignitas assisted suicide clinic in Zurich Switzerland, possibly with the help of the Right to Die Society of Canada. MacDonald, who lived many years with Multiple Sclerosis (MS), died on June 8, 2007. An obituary listed in the Halifax Chronicle Herald on June 20, 2007 concluded: "Last, but not least, we would like to thank Herr Ludwig Minelli, and the members of Dignitas in Zurich (Bernard and "Gaby", in particular), for helping Elizabeth deliver herself from the burden of a life which had...
  • Researchers Use Protein to Reverse Multiple Sclerosis in Mice

    06/13/2007 4:22:07 PM PDT · by cgk · 9 replies · 344+ views
    Fox News ^ | 6-13-07 | Katherine Tweed
    Nobody knows what causes , the nervous system disease that affects more than 400,000 Americans, but new research sheds light on why the body is attacking itself and how to reverse it. Researchers at the Stanford University School of Medicine have discovered how one protein could turn the tide against the degeneration found in the brains of MS patients, and actually reverse some of the worst effects of the disease. The protein - alphaB-crystallin - is not usually found in the brain, but in the lens of the eye. It only develops in the brain in response to nerve cells...
  • Vanity: Multiple Sclerosis and Cost of Medication

    02/27/2007 11:44:38 AM PST · by Puddleglum · 23 replies · 1,199+ views
    self
    To all Freepers and family members who have MS (multiple sclerosis): how much of the cost of your injectable does your insurance cover, if you use betaseron or copaxane or avonex? I was shocked this year to learn my wife's medicine is now a non-preferred drug and that we pay 30% of the cost, which is $500 a month. Now that's a lot better than paying the full price, but it is still very high. I have always had it covered as a flat co-pay before - say $50. Are there ways to reduce the cost or do I have...
  • Pregnancy hormone may offer hope for MS patients

    02/21/2007 1:25:04 PM PST · by nypokerface · 21 replies · 662+ views
    Reuters ^ | 02/21/07 | Will Dunham
    WASHINGTON (Reuters) - Scientists intrigued by the fact that multiple sclerosis can slip into remission when women are pregnant said on Tuesday a pregnancy-related hormone may offer great promise for treating the neurological disease. Researchers at the University of Calgary said a study involving mice showed that a hormone called prolactin triggers production of myelin, a fatty substance that insulates nerve cells in the brain and spinal cord. In multiple sclerosis, the immune system, which normally protects the body, is believed to attack the myelin that coats nerve cells, causing a worsening loss of sensation and movement that can range...
  • Botox isn't just for wrinkles anymore

    01/29/2007 7:50:15 AM PST · by neverdem · 2 replies · 197+ views
    WABC-TV ^ | Jan 26, 2007 | Dr. Jay Adlersberg
    Botox isn't just for helping get rid of wrinkles. There is a new use for it. Dr. Jay Adlersberg has more. If Botox can paralyze the muscles that cause wrinkles, how about using it for tight muscles in other places? That's what some doctors are doing to help patients with cerebral palsy and strokes. Botox is helping children and adults alike. Nine-year-old Andrew Carter is not afraid to fall. And he refuses to let cerebral palsy get the best of him. When Andrew would try to move, his muscles would fight him, jerking him around. It's a condition called spasticity....
  • Good Poison? Carbon Monoxide May Stifle Multiple Sclerosis

    01/26/2007 3:57:01 PM PST · by blam · 20 replies · 726+ views
    Science News ^ | 1-27-2007 | Nathan Seppa
    Good Poison? Carbon monoxide may stifle multiple sclerosis Nathan Seppa Small amounts of carbon monoxide might alleviate symptoms of multiple sclerosis, a study in mice suggests. The finding may offer a treatment for MS, which strikes when a person's immune system damages the fatty sheaths that protect nerve fibers in the brain and spinal cord. At first glance, the approach seems fraught with problems. Carbon monoxide inhalation can be lethal. But the body makes the molecule naturally in small amounts when an enzyme called heme-oxygenase-1 (HO-1) breaks down a portion of the blood protein hemoglobin. That enzyme might act as...
  • A Dose of Worms, Please (multiple sclerosis head's up!)

    01/20/2007 9:56:21 PM PST · by neverdem · 65 replies · 1,563+ views
    ScienceNOW Daily News ^ | 17 January 2007 | Dan Ferber
    A prolonged bout of intestinal parasites seems to slow the decline of patients with multiple sclerosis, according to a study released today. The results suggest that immune-modulating molecules from parasites could be developed into drugs to ease autoimmune diseases, and that by conquering parasite infections, modern medicine may have inadvertently increased our vulnerability to these illnesses. Autoimmune diseases such as multiple sclerosis (MS) occur far more often in developed countries than in developing countries. And parasitic infections, which have been beaten down in the United States, are still common in South America and elsewhere in the developing world, says neuroimmunologist...
  • Final Testing of MS [Multiple Sclerosis] Drug Launched (+ Tysabri info)

    01/11/2007 7:16:57 AM PST · by cgk · 7 replies · 277+ views
    Final testing of MS drug launchedBiogen Idec said it has launched final, Phase 3 testing of an oral drug to treat multiple sclerosis. The Massachusetts company, which has a research campus in San Diego, said the drug will be tested in more than 2,000 patients in North America. The studies of BG-12, as the drug is known, are expected to last two years. The drug would be the third in Biogen Idec's portfolio of multiple sclerosis medicines. In June, the company reintroduced the drug Tysabri with partner Elan Pharmaceuticals based on a risk-management plan that stipulated it must be administered...
  • Study: Vitamin D protects against MS

    12/19/2006 10:02:32 PM PST · by Coleus · 39 replies · 953+ views
    Chicago Tribune ^ | 12.19.06 | Ronald Kotulak
    Higher levels of vitamin D in the blood may lower the risk of multiple sclerosis (MS), research suggests. Previous studies have suggested vitamin D may have a protective effect - but the evidence has been inconclusive. A Harvard School of Public Health team measured levels of the vitamin in large numbers of US military personnel. The study, published in the Journal of the American Medical Association, found the risk of MS fell as blood levels of the vitamin rose. MS is among the most common neurological diseases affecting around two million people worldwide. The researchers uncovered 257 cases of MS...
  • Real-World Successes of Adult Stem Cell Treatments

    12/02/2006 7:28:38 PM PST · by Coleus · 3 replies · 581+ views
    FRC ^ | Mr. Bradley R. Hughes Jr.
    With increasing frequency, American citizens and others from around the globe are experiencing newfound freedom from disease, affliction, and infirmity. Individuals' lives are forever changed with the strengthened faith and renewed hope that arise from healed bodies and physical restoration. These seemingly miraculous cures are the result of adult stem cell treatments. Yet the debates in the popular media tend to ignore and obscure the medical breakthroughs made by adult stem cell research--success that has conspicuously eluded embryonic stem cell treatments.[1]  Adult stem cells (or, more accurately, tissue stem cells) are regenerative cells of the human body that possess the...
  • Stem Cell Clinic Shut Down (Gave stem cells "UNFIT" for humans to MS patients)

    10/07/2006 11:30:40 AM PDT · by cgk · 11 replies · 276+ views
    Therapeutics Daily/Birmingham Post ^ | 10-7-06 | Rhona Ganguly
    Stem cell clinic shut down The Birmingham Post - Oct. 07, 2006 A clinic which put patients at risk of contracting HIV and CJD through its use of stem cells classified as unfit for human use has been closed down by Dutch health bosses.The Rotterdam-based Pre-ventief Medisch Centrum (PMC), which charged one Midlands MS sufferer pounds 14,000 for treatment, has been ordered to stop trading immediately by the Netherlands Health Care Inspectorate.The company had been using stem cells provided by UK-registered company Advanced Cell Therapeutics (ACT) to treat patients with Multiple Sclerosis and other debilitating illnesses.During an investigation into PMC,...
  • You beauty! City pioneers use Botox to fix bladder problems (MS patients)

    09/21/2006 12:59:59 PM PDT · by cgk · 12 replies · 498+ views
    Edinburgh News ^ | 9-18-06 | Jennifer Veitch
    You beauty! City pioneers use Botox to fix bladder problems JENNIFER VEITCH PIONEERING surgeons are using the beauty treatment Botox to cure bladder problems in multiple sclerosis sufferers. Until now the procedure, which involves injecting botulinum toxin, has been used to reduce lines and wrinkles. However, at Edinburgh's Western General Hospital, it has dramatically reduced incontinence among MS patients, and it could now be trialed on other people who suffer from bladder complaints. Doctors have been injecting tiny quantities of Dysport, a brand of botulinum toxin, directly into the bladder wall. The procedure has cured the bladder problems in 90...
  • Vitamin 'may block MS disability'

    09/21/2006 12:44:50 PM PDT · by Nachum · 13 replies · 847+ views
    BBC News ^ | 9/21/2006 | Staff
    Vitamin shots may help protect multiple sclerosis patients from severe long-term disability, a study suggests. Currently, there is no effective treatment for the chronic progressive phase of MS, when serious disability is most likely to appear. Researchers cut the risk of nerve degeneration in mice with MS-type symptoms by giving them a form of vitamin B3 called nicotinamide. The Children's Hospital Boston study appears in the Journal of Neuroscience. MS, which affects about 85,000 people in the UK, is a disease of the central nervous system. It causes the break down of the myelin sheath, a fatty protein, which coats...
  • Adult Stem Cells: It's Not Pie-in-the-Sky

    03/13/2005 4:26:27 PM PST · by DaveLoneRanger · 23 replies · 1,482+ views
    Focus on the Family ^ | February 3, 2005 | Carrie Gordon Earll
    Embryonic stem cells have not cured or successfully treated a single patient. Contrast that with the more than 70 conditions that are treatable using non-embryonic stem cell therapies. One of the hottest debates in bioethics today surrounds research using stem cells taken from either in vitro fertilization or cloned human embryos. From state legislatures and the halls of Congress to the United Nation, the controversy over whether to ban (or fund) such research rages. Human cloning for embryonic stem cell research creates human embryos virtually identical to a patient’s genetic composition. The embryo’s stem cells are then harvested — a...
  • Adult Stem-Cell Treatments: A Better Way

    12/02/2005 3:27:08 PM PST · by Coleus · 9 replies · 650+ views
    Concerned Women for America ^ | 12.01.05 | Stephanie Porowski & Emma Elliott
    Adult stem-cell research may lead one day to cures for terminal and debilitating diseases "I hope we will always be guided by both intellect and heart, by both our capabilities and our conscience." -President George W. Bush1 Few areas of scientific study hold as much potential as adult stem-cell research. This research is already generating medical breakthroughs and treatments for debilitating diseases and disabilities, such as spinal cord injuries, sickle cell anemia and Parkinson's. Indeed, scientists laud stem-cell treatments as the "miracle cure" of the 21st century. Unlike so many areas of biotechnology, adult stem cells do not spark a...
  • The blend of drugs that can 'stop MS in its tracks'

    07/22/2006 5:22:19 PM PDT · by annie laurie · 36 replies · 1,522+ views
    Daily Mail ^ | 21st July 2006 | EMILY COOK
    Multiple Sclerosis sufferers were offered the hope of a normal life today after doctors discovered a pioneering drug treatment. A five-year study, which is due to be published in next month's Journal of Neurology, found that patients with the aggressive form of MS had a reduced relapse rate of 90 per cent under the regime. Background • Click here for our short guide to MS A treatment offering fresh hope for sufferers of multiple sclerosis has been discovered by British scientists. They are pioneering a regime which uses a combination of drugs to halt the ravages of the devastating neurological...
  • Stem Cells Found in Adult Skin Can be Transplanted and Function in Mouse Models of Disease

    06/14/2006 1:32:33 PM PDT · by LibWhacker · 4 replies · 260+ views
    Bio.com ^ | 6/14/06
    06/14/06 -- Researchers at The Hospital for Sick Children (SickKids) and the University of Calgary have found that stem cells derived from adult skin can create neural cell types that can be transplanted into and function in mouse models of disease. This research is reported in the June 14, 2006 issue of The Journal of Neuroscience. SickKids researchers previously discovered what type of cells can be made from these stem cells (called skin-derived precursors, or SKPs) based on the role played by neural-crest stem cells during embryogenesis. In addition to generating the peripheral nervous system, neural crest stem cells generate...
  • MS woman in stem cell therapy hope

    05/07/2006 6:58:19 PM PDT · by Coleus · 12 replies · 675+ views
    BBC ^ | 05.05.06 | Anna Lindsay
    Patricia is injected with about one million cord blood stem cells Patricia Frost is a desperate woman. The multiple sclerosis she has fought for 14 years has slowly taken over her body and speech.The 66-year-old has not been able to walk for a decade and lost the use of her arms within the past year - leaving her unable to feed, wash or dress herself.  After being told there is nothing more her British doctors can do for her, except to help ease her pain, Patricia decided to take a huge gamble with her health.  Along with her husband,...
  • Study: Bone Marrow Stem Cells May be Successful in Treating Parkinson's and MS

    05/02/2006 4:38:17 PM PDT · by wagglebee · 20 replies · 501+ views
    LifeSiteNews ^ | 5/2/06 | LifeSiteNews
    NEW ROCHELLE, N.Y., May 2, 2006 (LifeSiteNews.com) - The results of a study published in the April issue of Stem Cells and Development suggest that human stem cells derived from bone marrow are predisposed to develop into a variety of nerve cell types, supporting the promise of developing stem cell-based therapies to treat neurodegenerative disorders such as Parkinson's disease and multiple sclerosis. Stem Cells and Development, a peer-reviewed journal published by Mary Ann Liebert, Inc., carries the paper, entitled "Human Mesenchymal Stem Cells Express Neural Genes, Suggesting a Neural Predisposition." (online here http://www.liebertpub.com/scd)The surprising results lend a new perspective...
  • New Findings Support Promise of Using Stem Cells to Treat Neurodegenerative Diseases

    05/02/2006 12:52:15 PM PDT · by Coleus · 14 replies · 435+ views
    The results of a study published in the April issue of Stem Cells and Development suggest that human stem cells derived from bone marrow are predisposed to develop into a variety of nerve cell types, supporting the promise of developing stem cell-based therapies to treat neurodegenerative disorders such as Parkinson's disease and multiple sclerosis. Stem Cells and Development is a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com  ). The paper, entitled "Human Mesenchymal Stem Cells Express Neural Genes, Suggesting a Neural Predisposition," is available free online at www.liebertpub.com/scd.  These surprising results lend a new perspective to stem cell...
  • Breakthrough in Autoimmune Disease Research - Stem Cell Research Gives New Hope to Patients

    04/10/2006 8:00:51 PM PDT · by neverdem · 27 replies · 1,532+ views
    ABC News Internet Ventures ^ | April 10, 2006 | NA
    Before seeking out Dr. Richard Burt of Northwestern Memorial Hospital, Kathy Hammons could barely care for her children as a result of the effects of lupus, an autoimmune disease in which the body attacks itself. She had been on oxygen for two years, was constantly fatigued, and was overweight from the steroids used to control her disease. "I would say before this option, they [lupus patients] hit a brick wall," Burt said. "They had nothing more, no further treatments." Burt's pioneering research, however, offered a new option. His breakthrough procedure uses a patient's stem cells to treat extremely severe cases...
  • WSJ: The FDA and MS

    04/07/2006 5:56:19 AM PDT · by OESY · 3 replies · 318+ views
    Wall Street Journal ^ | April 7, 2006 | Editorial
    ...The therapy in question is Tysabri, and for many MS patients it appears to halt progression of the degenerative neurological disorder. But a year ago... corporate partners Biogen and Elan "voluntarily" withdrew their drug because of FDA pressure and litigation fear after two patients developed a rare brain infection. That infection might have been linked to Tysabri, since the drug works by suppressing parts of the immune system. But these patients also had other immuno-suppressive therapies, and in any case the MS patients were almost all willing to run the risk.... But shortly before the deadline, the FDA announced it...
  • Study finds that high dose of MS drug works better

    04/05/2006 5:00:23 PM PDT · by wagglebee · 13 replies · 353+ views
    Reuters ^ | 4/5/06 | Deena Beasley
    LOS ANGELES (Reuters) - A high dose of Teva Pharmaceutical Industries Ltd.'s multiple sclerosis drug Copaxone is more effective at limiting relapses and brain lesions than the standard dose, without more side effects, researchers said on Wednesday. "For some people a higher dose may work better," said Dr. Jeffrey Cohen of the Cleveland Clinic's MS research center and lead investigator of a small nine-month trial comparing the two doses. The study, funded by Israel-based Teva, found that a 40 milligram injection of Copaxone reduced inflammatory disease activity 38 percent more than a 20 mg dose. Rates of side effects, mainly...
  • Prayer Request for FReeper cgk

    03/29/2006 5:16:30 PM PST · by wagglebee · 306 replies · 4,202+ views
    3/29/06
    I just learned from FReeper cgk who has multiple sclerosis that many of her symptoms are returning. Her doctor has determined that she can be treated at home and does not need to be hospitalized at this time. She is grateful for this because it will allow her to stay home with her little girl. Please post your prayers to cgk. Thank You and God Bless you all.
  • Many Players on the Field (MS drug research picking up)

    03/27/2006 9:22:22 AM PST · by cgk · 7 replies · 603+ views
    LA Times ^ | 3-27-06 | Mary Beckman
    Many players on the field Hailed multiple sclerosis drug Tysabri is in FDA limbo, but researchers continue to attack the disease from all angles. By Mary Beckman Special to The Times March 27, 2006 STEPHANIE YELLIN-MEDNICK got through last year without the tingling in her hands that causes her to drop things or the weakness in her legs that knocks her off balance. Then the Food and Drug Administration pulled the drug that was helping her — Tysabri — off the market because of rare cases of brain infection in a few people taking it. "It was like a rug...
  • Multiple Sclerosis Drug Combined with Lipitor May Stop or Reverse Disease

    03/21/2006 9:33:29 AM PST · by cgk · 9 replies · 665+ views
    Multiple Sclerosis Drug Combined with Lipitor May Stop or Reverse Disease - Dosages Cut in Half with Fewer Negative Side Effects March 16th 2006 Lipitor Combining treatments may improve outcomes for patients with Multiple Sclerosis (MS), according to research done on mice and published online by the Journal of Clinical Investigation. Scott S. Zamvil and colleagues at the University of California, San Francisco found that mice treated with a combination of Glatiramer acetate (GA) and atorvastatin (Lipitor) demonstrated “a significant prevention and reversal of clinical MS severity” of MS symptoms.  Lipitor is a cholesterol lowering drug that has previously been...
  • 'Elephant Man couldn't resist drug test money'

    03/20/2006 5:31:22 AM PST · by Born Conservative · 46 replies · 1,407+ views
    Daily Mail ^ | 3/20/2006 | REBECCA ENGLISH
    The drug trial victim whose head ballooned in size so much that his sobbing girlfriend said he resembled the Elephant Man said he couldn't resist the £2,000 fee for the tests. Mohammed Abdalla, 28, had planned to use his £2,000 fee for being a guinea pig to make his family in Egypt financially secure. He wanted to set up his brother Mahmood in business and look after his father, an imam, and desperately ill mother. Yesterday, as the London bar manager's dreams were disclosed, it emerged that scientists had warned about the damage the drug could do to human tissue...
  • Protein Fragment May Generate First Simple Test For Multiple Sclerosis

    03/12/2006 3:46:23 PM PST · by cgk · 9 replies · 395+ views
    Protein Fragment May Generate First Simple Test For Multiple Sclerosis Johns Hopkins scientists report the discovery of a protein found only in cerebrospinal fluid that they say might be useful in identifying a subgroup of patients with multiple sclerosis (MS) or identifying those at risk for the debilitating autoimmune disorder. MS strikes over 10,000 Americans each year, most of whom are women, and causes weakness, numbness, a loss of muscle coordination, and problems with vision, speech, and bladder control. It is a disorder in which the immune system destroys myelin, the covering of nerves that helps transmit signals. Cerebrospinal fluid...
  • Lenten “Listening”: Last “Rights” for Neurology (must read)

    03/11/2006 6:09:56 PM PST · by sionnsar · 71 replies · 910+ views
    Clueless Christian ^ | 3/11/2006 | Shari deSilva, MD
    On June 13th, I will have been a physician for twenty five years. Twenty four of those years, exactly one half of my life, will have been spent as a neurologist. I would like, therefore, to state for the record, how grateful I am to have been allowed to practice as a neurologist, during this, the profession’s best of times.When I first began my neurology residency 24 years ago, the practice of neurology was described to me in the phrase “diagnose and adios”. Neurologists were great at diagnosing, based on history and physical examination, where precisely a lesion in the...
  • Vaccine could stop MS in its tracks

    03/10/2006 5:42:57 PM PST · by Coleus · 27 replies · 927+ views
    New Scientist ^ | 03.09.06 | Andy Coghlan
    THE immune cells that attack the brains and nerves of people with multiple sclerosis could be turned into a weapon against the disease.This month sees the beginning of a trial of a personalised vaccine for MS, designed to rein in and destroy the renegade white blood cells that attack myelin cells lining the brain and nerves of patients.To make the vaccine, PharmaFrontiers of Woodlands, Texas, takes blood from an MS patient and extracts a sample of these renegade cells. The cells are then multiplied and weakened with radiation before being re-injected into the patient, whose immune system will then recognise...
  • FDA panel supports MS drug's market return

    03/08/2006 11:35:06 PM PST · by neverdem · 4 replies · 202+ views
    Seattle Post-Intelligencer ^ | March 8, 2006 | ANDREW BRIDGES
    ASSOCIATED PRESS WASHINGTON -- A promising drug for multiple sclerosis should be returned to the market despite questions about a rare brain disease, scientific advisers told the government Wednesday - even as they continued to grapple with just who should be allowed to use it. The unanimous vote by advisers to the Food and Drug Administration came amid regulators' own concerns about the drug Tysabri, and whether there is any way to minimize risk from the apparent rare side effect. But the advisers were debating some controls on who could use the drug, agreeing to a manufacturer proposal for a...
  • F.D.A. Allows Some Patients to Resume M.S. Drug

    02/15/2006 10:35:38 PM PST · by neverdem · 7 replies · 263+ views
    NY Times ^ | February 16, 2006 | ANDREW POLLACK
    The Food and Drug Administration said yesterday that it would allow some patients in a clinical trial to resume treatment with Tysabri, a multiple sclerosis drug that was abruptly withdrawn from the market a year ago because of safety risks. The decision appears to strengthen the probability that Tysabri, developed by Biogen Idec and Elan, will be allowed to return to the market. The F.D.A. is scheduled to decide on that question by the end of March. "You can certainly deduce that we've concluded that there are at least some people for whom the risk is worth it," Dr. Robert...
  • Why many disabled fight assisted suicide

    02/09/2006 10:45:16 AM PST · by SmithL · 106 replies · 1,247+ views
    Sacramento Bee ^ | 2/9/6 | Clea Benson
    Lilibeth Navarro, a community activist in Los Angeles who became disabled after surviving polio as a child, remembers visiting her doctor after a near-fatal bout with pneumonia. The physician, she recalls, urged her to sign a do-not-resuscitate order so that it could be on file the next time she was admitted to the hospital. To Navarro, 50, the doctor's attitude appeared markedly different from the manner medical professionals seemed to display toward family members such as her 93-year-old grandmother. Doctors presumed, she said, that her fully mobile grandmother would want them to use all medical technology at their disposal to...
  • Fat Hormone Tied to Multiple Sclerosis

    01/24/2006 2:45:40 PM PST · by cgk · 6 replies · 312+ views
    WebMD ^ | 1-12-06 | Miranda Hitti
    Fat Hormone Tied to Multiple Sclerosis Italian Study: Blocking the Hormone Leptin Curbed Similar Disease in Mice By Miranda Hitti WebMD Medical News Reviewed By Louise Chang, MD on Thursday, January 12, 2006 Jan. 12, 2006 -- Blocking the hormone leptin may help prevent or slow multiple sclerosis (MS).The report comes from Italian researchers and appears in The Journal of Clinical Investigation.The Italian study didn't include any people. Instead, the scientists studied female mice with an MS-like disease.Leptin is a hormone that's mostly made by fatty tissue of the body. Commonly associated with obesity, leptin plays a role in regulating weight and appetite.Leptin also affects...
  • Getting a Grip on Being Cool on a Hot Day

    12/13/2005 4:31:38 PM PST · by neverdem · 19 replies · 651+ views
    NY Times ^ | December 13, 2005 | AIMEE BERG
    Every year, athletes die of heat stroke. Road crews, firefighters and soldiers work and fade in sweltering conditions. Millions of others suffer from medical problems made worse by the heat. Now two inventors have come up with a device that may provide a solution. For two years, the Defense Advanced Research Projects Agency, which gave us the Internet, has been financing the research on a hand-held device that essentially cools the body from the inside. The device, CoreControl, is a coffee pot-size chamber with a cold metal cone in the center. The user grips the cone and holds it for...
  • Comedian Richard Pryor dies at 65

    12/10/2005 3:24:07 PM PST · by summer · 299 replies · 6,061+ views
    CNN Politics - The Situation Report ^ | Dec. 10, 2005 | AP via CNN
    LOS ANGELES (AP) -- Richard Pryor, the caustic yet perceptive actor-comedian who lived dangerously close to the edge both on stage and off, has died, his ex-wife said Saturday. He was 65. Pryor died of a heart attack at his home in the San Fernando Valley sometime late Friday or early Saturday, Flyn Pryor said. He had been ill for years with multiple sclerosis, a degenerative disease of the nervous system. The comedian was regarded early in his career as one of the most foul-mouthed comics in the business, but he gained a wide following for his expletive-filled but universal...
  • FDA Agrees to Priority Review for Tysabri®

    11/21/2005 10:26:11 AM PST · by Magnolia · 10 replies · 399+ views
    National Multiple Sclerosis Society website ^ | November 18, 2005 | National Multiple Sclerosis Society
    The sponsors of Tysabri (natalizumab), Biogen Idec and Elan Corporation, announced today that the U.S. Food and Drug Administration has agreed to conduct a “Priority Review” of their application to return the drug back to the market. Tysabri was withdrawn in February 2005 due to safety concerns and is currently being re-evaluated by the FDA. (Read background information about Tysabri.) Agreeing to a Priority Review means that the FDA has approximately six months from the late September 2005 submission date to review the safety and efficacy data submitted by the companies, to seek advice from experts and comments from persons...
  • Umbilical Cord Stem Cells Offer Hope to MS-Stricken Teen

    11/20/2005 5:49:18 PM PST · by wagglebee · 43 replies · 1,144+ views
    LifeSiteNews.com ^ | 11/18/05 | Terry Vanderheyden
    INVERNESS, Scotland, November 18, 2005 (LifeSiteNews.com) - A British teen who has multiple sclerosis now claims she is walking after umbilical cord stem cell therapy she traveled abroad to receive. Wheelchair-bound since 2003, 19 year-old Amanda Bryson told The Herald that she has been walking daily since immediately after her treatment from a private clinic in the Netherlands Friday. Believed to be the only British beneficiary of the umbilical cord stem cell therapy, Bryson said this week, "It sounds shocking, but I could feel the difference after just five minutes. Since the treatment I have been transformed. I am doing...