Free Republic

Marijuana has a reputation for making people dash to the kitchen (or the nearest convenience store). New research shows why and helps explain how a hormone called leptin usually keeps the appetite under control. The results may help scientists design better diet drugs. Researchers have known for several years that a connection exists between leptin and cannabinoids, the molecules in the brain that stimulate appetite and that are related to those found in marijuana (ScienceNOW, April 11 2001). Mice that don't make leptin have oversized appetites, for example, and they have unusually high concentrations of cannabinoids in the hypothalamus. But...

They are the building blocks of flab, the wages of cheesecake, the bloated little sacks of grease that make more of us - more than we can fit into our pants. Scorned and despised, they are sucked out surgically by the billions from bulging backsides, bellies and thighs. But they are not without admirers. "Fat cells are beautiful cells to look at," said Dr. Philipp E. Scherer, an associate professor of cell biology and medicine at Albert Einstein College of Medicine in New York. "I've been working with them for 10 years and I still enjoy looking at them." On...

New studies in mice suggest that the hormone leptin can fundamentally change the brain's circuitry in areas that control appetite. Leptin acts during a critical period early in life, possibly influencing how much animals eat as adults. And later in life, responding to how much fat is on an animal's body, it can again alter brain circuitry that controls how much is eaten. Researchers say the findings, published today in the journal Science, are a surprise and add new clues to why weight control is so difficult in some humans. Scientists knew that leptin is released by fat cells and...

Two years ago, a young organ transplant doctor told me a harrowing story. Recently he had stood by and watched helplessly as a 15-year-old African-American girl died from an enlarged heart. A transplant might have saved her, but high blood pressure, diabetes, and a body mass of more than 400 pounds made surgery impossible. The memory haunted him as he continued to treat more and more children experiencing the deadly effects of chronic obesity. Mostly poor black kids, they marched through his office suffering from high cholesterol, high blood pressure, enlarged hearts, and adult-onset diabetes that promised to fill their...