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Study Evaluating Intravenous Progesterone Formulation BHR-100 to Treat Traumatic Brain Injury Set to Complete in 2013 BHR Pharma's SyNAPSe® clinical trial is now enrolling patients suffering from severe traumatic brain injury (TBI) at 14 sites in Thailand, China and Russia. The trial currently has 153 participating sites (Level 1 and 2 trauma centers) worldwide. The 500th of 1,180 patients needed to complete the global Phase III, multi-center trial was enrolled at the end of May in the United States. SyNAPSe is evaluating the effectiveness of BHR-100, a... --snip-- TBI is a serious public health problem that affects more than 1.7...

In November 2008, when he was just 6, William Moller had his first epileptic seizure, during a reading class at school. For about 20 seconds, he simply froze in place, as if someone had pressed a pause button. He could not respond to his teacher. This is known as an absence seizure, and over the next year William, now 10, who lives with his family in Brooklyn, went from having one or two a day to suffering constant seizures. Not all were absence seizures; others were frightening tonic-clonics, also known as grand mals, during which he lost consciousness and convulsed....

Researchers at NYU School of Medicine have, for the first time, identified a single gene that simultaneously controls inflammation, accelerated aging and cancer. "This was certainly an unexpected finding," said principal investigator Robert J. Schneider, PhD, the Albert Sabin Professor of Molecular Pathogenesis, associate director for translational research and co-director of the Breast Cancer Program at NYU Langone Medical Center. "It is rather uncommon for one gene to have two very different and very significant functions that tie together control of aging and inflammation. The two, if not regulated properly, can eventually lead to cancer development. It's an exciting scientific...

A unique new medicine that can start and accelerate healing of diabetic and other chronic wounds is being developed at Umeå University in Sweden. After several years of successful experimental research, it is now ready for clinical testing. Behind this new medicine is a group of researchers at the Department of Medical Chemistry and Biophysics who have made the unique finding that the protein plasminogen is a key-regulator that initiates and accelerates wound healing by triggering the inflammatory reaction. Their discovery is now being published in the journal Blood. “Today we have the knowledge needed to develop a medicine,” says...

Scientists from Queen Mary, University of London have found a new therapeutic target to combat inflammation. The research, published in the journal Cellular and Molecular Life Sciences, revealed tiny organelles called primary cilia are important for regulating inflammation. The findings could lead to potential therapies for millions of people who suffer from arthritis. Dr Martin Knight who led the research at Queen Mary's School of Engineering and Materials Science said: "Although primary cilia were discovered more than a century ago, we're only beginning to realise the importance they play in different diseases and conditions, and the potential therapeutic benefits that...

I can't find the article that Rush was talking about. Does anybody have a link?

Last year, he began taking Anatabloc, an new anti-inflammatory pill. He liked it so much, he began recommending it to friends, and the company has become one of his sponsors. "It's not going to help my back, but my hands felt better and the areas around the back where I've had hiccups in the past, I haven't had," said Couples, who said his inflammation level has come down. "I'm not going to tell you that it's a wonder drug, but I would say I feel 30 percent better. If I feel 70 percent on a bad day, instead of 50...

BUFFALO, N.Y. -- Exenatide, a drug commonly prescribed to help patients with type 2 diabetes improve blood sugar control, also has a powerful and rapid anti-inflammatory effect, a University at Buffalo study has shown. The study of the drug, marketed under the trade name Byetta, was published recently in the Journal of Clinical Endocrinology and Metabolism. "Our most important finding was this rapid, anti-inflammatory effect, which may lead to the inhibition of atherosclerosis, the major cause of heart attacks, strokes and gangrene in diabetics," says Paresh Dandona, MD, UB Distinguished Professor in the Department of Medicine, UB School of Medicine...

Pharmacists of the University Jena analyze why men suffer more rarely from inflammatory diseases than women It’s all down to the testosterone: men are usually more muscular than women, they have deeper voices and more body hair. And – men are less susceptible to inflammatory diseases and allergies than women. This is also due to the male sex hormones as pharmacists at the Friedrich Schiller University Jena (Germany) have shown in a recent study. “It is mostly women who are affected by diseases like rheumatoid arthritis, psoriasis or asthma“, Professor Dr. Oliver Werz from the Jena University explains. Although this...

Your body is in a constant battle to maintain its delicate acid alkaline balance. Over acidity can cause a host of diseases and other problems to manifest in the body. This makes a healthy alkaline food diet all the more important for the sick, to adhere to a 20/80 rule acid/alkaline diet. Those suffering from fibromyalgia need to pay close attention to their acid/alkaline balance. St. Martins Press – Your favorite snack or dessert could trigger symptoms of fibromyalgia. Tender pain, fatigue, trouble with memory and digestive problems are just a few of the problems experienced by women with fibromyalgia....

Researchers at BRIC, the University of Copenhagen, have discovered that the human body can create its own vaccine, which boosts the immune system and helps prevent chronic inflammatory diseases. The researchers’ results have just been published in the prestigious Journal of Clinical Investigation and may have significant consequences in developing new medicine.Researchers at the Biotech Research and Innovation Centre (BRIC) at the University of Copenhagen have discovered a protein normally found in the body that can act to prevent chronic tissue inflammation. When administered in the form of a therapeutic vaccine it is able to effectively prevent and treat a...

Scientists at the Univ. of Pennsylvania School of Medicine discovered that a dietary antioxidant found in such vegetables as broccoli and cauliflower protects cells from damage caused by chemicals generated during the body’s inflammatory response to infection and injury. The finding has implications for such inflammation-based disorders as cystic fibrosis (CF), diabetes, heart disease, and neurodegeneration. Through cell-culture studies and a synthesis of known antioxidant biochemistry, Zhe Lu, professor of physiology, Yanping Xu , senior research investigator, and Szilvia Szép , postdoctoral researcher, showed that the antioxidant thiocyanate normally existing in the body protects lung cells from injuries caused by...

Feeding obese mice omega-3 fatty acids reduced inflammation that can lead to diabetes, a new study finds. By studying fat tissue in the mice consuming fish oil, researchers found omega-3 fatty acids seem to act on a particular receptor on cells, GPR120, which, when activated, blocks inflammatory processes. Chronic inflammation can lead to insulin resistance, a precursor to diabetes. Therefore, "if we can fix the inflammation part, it's possible that we could prevent insulin resistance or even ameliorate diabetes," Talukdar explained.

Virginia Commonwealth University Massey Cancer Center researchers have uncovered a new link between chronic inflammation and cancer. Although cancers do not always cause inflammation, chronic inflammation is known to help tumor cells grow. In an article published in the June issue of Nature, VCU Massey scientists Sarah Spiegel, Ph.D., and Tomasz Kordula, Ph.D., and their co-authors examine how sphingosine-1-phosphate (S1P), a lipid mediator in the blood that influences immune cell circulation, also regulates inflammation and cancer. They reported that S1P is a missing cofactor that is required for the activity of TRAF2, the key regulator of NF-kappaB, which acts as...

Chokeberry bushes have for centuries been residents of eastern deciduous forests where their bright red and dark purple fruits continue to be favorite snacks of local bird species. Native Americans have also traditionally eaten dried chokeberries and prepared teas from parts of the plant, and several domesticated varieties now grace contemporary lawns and gardens from coast to coast. However, the chokeberry (Aronia) is enjoying a new claim-to-fame as a potentially powerful antioxidant, and can now be found for sale in the dietary supplement and "health food" aisles of your local pharmacies and grocery stores. What makes the humble chokeberry so...

With the government’s blessing, a drug giant is about to expand the market for its blockbuster cholesterol medication Crestor to a new category of customers: as a preventive measure for millions of people who do not have cholesterol problems... --snip-- But critics said the claim of cutting heart disease risk in half — repeated in news reports nationwide — may have misled some doctors and consumers because the patients were so healthy that they had little risk to begin with. The rate of heart attacks, for example, was 0.37 percent, or 68 patients out of 8,901 who took a sugar...

SALT LAKE CITY—Treating virulent influenza, sepsis, and other potentially deadly infections long has focused on looking for ways to kill viruses and bacteria. But new research from the University of Utah and Utah State University shows that modulating the body's own overeager inflammatory response to infection may help save more lives. In a study published March 17 in Science Translational Medicine, researchers led by U of U cardiologist Dean Y. Li, M.D., Ph.D., professor of internal medicine and director of the Molecular Medicine Program, shows that protecting blood vessels from hyper-inflammatory response to infection reduced mortality rates in mouse models...

The signaling molecule CD95L, known as "death messenger," causes an inflammatory process in injured tissue after spinal cord injuries and prevents its healing. This discovery was published by scientists of the German Cancer Research Center. In mice, the researchers found out that if they switch off CD95L, the injured spinal cord heals and the animals regain better ability to move. Therefore, substances which block the death messenger might offer a new approach in the treatment of severe inflammatory diseases. A couple of years ago, Dr. Ana Martin-Villalba of the German Cancer Research Center already succeeded in reducing the effects of...

Appearing in the January 2010 issue of JLRFor those who do not drink, researchers have found that six essential oils –from thyme, clove, rose, eucalyptus, fennel and bergamot—can suppress the inflammatory COX-2 enzyme, in a manner similar to resveratrol, the chemical linked with the health benefits of red wine. They also identified that the chemical carvacrol was primarily responsible for this suppressive activity. These findings, appearing in the January issue of Journal of Lipid Research, provide more understanding of the health benefits of many botanical oils and provide a new avenue for anti-inflammatory drugs. Essential oils from plants have long...

COLLEGE STATION – A gene commonly studied by cancer researchers has been linked to the metabolic inflammation that leads to diabetes. Understanding how the gene works means scientists may be closer to finding ways to prevent or cure diabetes, according to a study by Texas AgriLife Research appearing in the Journal of Biological Chemistry. "Because we understand the mechanism, or how the gene works, we believe a focus on nutrition will find the way to both prevent and reverse diabetes," said Dr. Chaodong Wu, AgriLife Research nutrition and food scientist who authored the paper with the University of Minnesota's Dr....