Free Republic

Leukemia, the blood cancer, is a group of hematopoietic malignancies. Many types of leukemia are associated with poor outcome. Unfortunately, during the past few decades, the first-line leukemia therapy has long been traditional chemotherapy with high cytotoxicity and low selectivity, such as the "7+3" strategy, i.e., a combination of cytarabine and doxorubicin. Side effects of such intensive chemotherapies are often severe, especially in older patients. Therefore, it is an urgent need to understand the mechanisms of leukemia, and develop novel targeted therapy based on such comprehension. In this work, Jiang's group first found through drug screening that opioid receptor agonists,...

The FDA warned doctors and patients Tuesday, June 7, 2016, that over-the-counter and prescription anti-diarrhea drugs, including Imodium, can cause potentially deadly heart problems when taken in large doses.... The primary ingredient in prescription Imodium and similar over-the-counter drugs is intended to control diarrhea. But abusers sometimes try to achieve heroin-like highs by taking massive doses, up to 300 milligrams at once, according to cases in the medical literature. Recommended doses range between 8 milligrams and 16 milligrams per day.