If you lived there you would get used to the altitude but being a low lander it is difficult. When we drive from Texas and take several days doing it I seem to adjust. But to fly to Denver, rent a car and be at 10,000 feet in a couple of hours, I think I am too old to do that again.
On one trip, an art workshop that I had looked forward to for a year, my heart pounded night and day and I could not fall asleep for a week. I was a basket case.
My husband has the opposite reaction, he falls asleep sitting up and has trouble staying awake.